Redistribution of a murine humoral immune response following removal of an immunodominant B cell epitope from a recombinant fusion protein
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Engineering filamentous phage carriers to improve focusing of antibody responses against peptides
2010, VaccineCitation Excerpt :Furthermore, it is not clear whether Ab responses elicited by the carrier affect or skew the Ab response against the targeted antigen. Several studies have shown that altering an immunodominant epitope (e.g., by point mutation or glycosylation) can redirect Ab responses to other epitopes on a peptide or protein [1,5–8] and can affect neutralizing activity [9]. However, to our knowledge no studies have addressed the possibility of altering a carrier protein's epitopes to improve the Ab response to an associated hapten, peptide or carbohydrate antigen.
Vaccination of mice with plasmids expressing processed capsid protein of foot-and-mouth disease virus-Importance of dominant and subdominant epitopes for antigenicity and protection
2007, VaccineCitation Excerpt :In parallel with variations in the G–H loop extensive variation in a discontinuous epitope (site D) has been observed [26]. Previous studies have shown that removing dominant epitopes can redirect the immune response towards less dominant epitopes [4,27]. In this study we have selectively modified recombinant FMDV antigen at two of the most variable and antigenic epitopes on the virus particle, and studied the influence of these changes on the immune response.
Generating conformation and complex-specific synthetic antibodies
2017, Methods in Molecular BiologyThe evolution within us
2015, Philosophical Transactions of the Royal Society B: Biological Sciences