The chemistry of taxol
References (85)
- et al.
Total synthesis of verticillene. A biomimetic approach to the taxane family of alkaloids
Tetrahedron
(1990) - et al.
Taxus alkaloids
- et al.
Verticillol, a novel type of conifer diterpene
Tetrahedron Lett.
(1964) - et al.
Chemical studies of 10-deacetyl baccatin III. Hemisynthesis of taxol derivatives
Tetrahedron
(1986) - et al.
Taxinine
Tetrahedron Lett.
(1963) - et al.
The biosynthesis of 3-dimethylamino-3-phenylpropanoic acid in yew
Tetrahedron Lett.
(1966) The Taxus alkaloids
- et al.
Application of the vicinal oxyamination reaction with asymmetric induction to the hemisynthesis of taxol and analogues
Tetrahedron
(1989) - et al.
Highly stereo-selective synthesis of α-hydroxy β-amino acids through β-lactams: application to the synthesis of the taxol and bestatin side chains and related systems
Tetrahedron Lett.
(1990) - et al.
Structure-activity study of cytotoxicity and microtubule assembly in vitro by taxol and related taxanes
Biochem. biophys. Res. Commun.
(1982)
Biosynthesis of flavan-3-ols and other secondary plant products from (2S)-phenylalanine
Phytochemistry
Analysis of anticancer drugs in biological fluids: determination of taxol with application to clinical pharmacokinetics
J. pharm. biomed. Anal.
Taxine. Part I. Isolation studies and the functional groups of O-cinnamoyltaxicin-I
J. chem. Soc.
HPLC separation of taxol and cephalomannine
J. Liq. Chromat.
The crystal and molecular structure of the diterpenoid baccatin V, a naturally occurring oxetan with a taxane skeleton
Acta Crystallogr. Sect. B
Taxa-4(16),11-diene-5α,9α,10β,13α-tetraol, a new taxane derivative from the heartwood of yew (T. baccata L.): X-ray analysis of a p-bromobenzoate derivative
Chem. Commun.
Analyse structurale et etude biochimique de produits isoles de l'if: Taxus baccata L. (Taxacess)
C.R. Acad. Sc. Paris, Serie II
Synthesis of a [3H]-labelled derivative of the microtubular poison taxol
J. Labelled Comp. Radiopharmac.
Cell culture as a means to produce taxol
Preparation of taxol derivatives as antitumor agents
Eur. Pat. Appl.
Acid-catalyzed cyclization of cembrene and isocembrol
J. org. Chem.
Insertion reactions of oxacarbenes generated photochemically from cyclobutanones
Structures of some taxane diterpenoids, baccatins-III, -IV, -VI, and -VII and 1-dehydroxybaccatin-IV, possessing an oxetan ring
J. chem. Soc. Chem. Commun.
An efficient, enantioselective synthesis of the taxol side chain
J. org. Chem.
Highly efficient, practical approach to natural taxol
J. Am. chem. Soc.
An improved synthesis of the taxol side chain and of RP 56976
J. org. Chem.
Synthesis of congeners and prodrugs. 3. Water-soluble prodrugs of taxol with antitumor activity
J. med. Chem.
Plantes de Nouvelle-Caledonie. 114. Taxanes Isolés des Feuilles d'Austrotaxus spicata compton (Taxacées)
Bull. Soc. chim. Fr.
Plantes de Nouvelle-Caledonie. 124. Taxanes Isoles des écorces de tronc d'Austrotaxus apicata compton (Taxacées)
Bull. Soc. chim. Fr.
5-Hydroxy-1,8-naphthalene carbolactone: esterification by the taxol “side chain”
Pharmazie
1-Oxabicyclobutonium ions can intervene in epoxycarbinyl and 3-oxetanyl solvolyses
J. Am. chem. Soc.
Taxol and derivatives: a biogenetic hypothesis
J. nat. Prod.
Structure of a synthetic taxol precursor: N-tert-butoxycarbonyl-10-deacetyl-N-debenzoyltaxol
Acta crystallogr.
Relationships between the structure of taxol analogues and their antimitotic activity
J. med. Chem.
Taxine. Part III. A revised structure for the neutral fragment from O-cinnamoyltaxicin-I
J. chem. Soc. C
Taxine. Part IV. The constitution of taxine-I
J. chem. Soc. C
Synthesis of the taxane ring system
J. Am. chem. Soc.
A synthesis of taxusin
J. Am. chem. Soc.
New taxanes from Taxus brevifolia, 2
J. nat. Prod.
Nomenclature of Organic Chemistry. Section F: Natural Products and Related Compounds
Eur. J. Biochem.
Enzyme-linked immunosorbent assay for the detection and semi-quantitative determination of taxane diterpenoids related to taxol in Taxus sp. and tissue cultures
J. Pharm. Belg.
Approaches to the synthesis of modified taxols
Cited by (331)
Combinatorial biosynthesis in yeast leads to over 200 diterpenoids
2024, Metabolic EngineeringTowards modern anticancer agents that interact with tubulin
2019, European Journal of Pharmaceutical SciencesCitation Excerpt :The current interest in tubulin binding drugs is due in large part to the success of the clinical treatments based on the taxanes PTX (29) and docetaxel (DTX) (30) as anticancer agents (Rowinsky and Donehower, 1995; Cortes and Pazdur, 1995) (Chart 3). PTX is a natural occurring product that was extracted from bark of the Pacific yew tree (Taxus brevifolia) (Kingston, 1991). Its anticancer activity was discovered in the sixties at the National Cancer Institute (NCI) during a large-scale screening program of plant products.
Complexation of Ca<sup>2+</sup> cation by the lateral chain of Paclitaxel (N-Benzoyl-ß-phenylisoserine): A theoretical study
2018, Computational and Theoretical ChemistryCitation Excerpt :The lateral side chain located at C13 is a N-benzoyl-3 phenylisoserine ester, later called LC. Kingston’s work has demonstrated that the lateral chain is important for biological activity and contribute to the overall activity of taxol [33]. It is suspected to be the potent moiety responsible for the antimitotic activity of Taxol [34–36].
Developments and future clinical outlook of taxane nanomedicines
2017, Journal of Controlled ReleaseIsolation and cytotoxicity evaluation of taxanes from the barks of Taxus wallichiana var. mairei
2015, Bioorganic and Medicinal Chemistry LettersThe Paternò-Büchi Reaction
2014, Comprehensive Organic Synthesis: Second Edition