Mapping of the chromosome 11 breakpoint of the t(4;11)(q21;p14–15) translocation

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Abstract

We describe the localization of the chromosome 11 breakpoint of a T-ALL translocation, t(4;11)(q21;p14–15), to sub-band 11p15.5. The breakpoint is located between the genes for insulin-like growth factor II (IGFII) and the M1 subunit of ribonucleotide reductase (RRM1). This region does not include any previously cloned genes involved in cancer.

References (18)

  • CD Bloomfield et al.

    Chromosomal abnormalities identify high-risk and low-risk patients with acute lymphoblastic leukemia

    Blood

    (1986)
  • C Sapienza

    Genome imprinting and carcinogenesis

    Biochemica et Biophysica Acta

    (1991)
  • JD Rowley

    Molecular cytogenetics: Rosetta Stone for understanding cancer—twenty-ninth G. H. A. Clowes Memorial Award lecture

    Cancer Res

    (1990)
  • JE Hardingham et al.

    A rare translocation (4;11)(q21;p14–15) in an acute lymphoblastic leukemia expressing T-cell and myeloid markers

    Cancer Genet Cytogenet

    (1992)
  • S Inoue et al.

    A variant translocation between chromosomes 4 and 11, t(4q;11p) in a child with acute leukemia

    Am J Ped Hemat Oncol

    (1985)
  • LM Secker-Walker et al.

    The (4;11) translocation in acute leukaemia of childhood: the importance of additional chromosomal aberrations

    Br J Haematol

    (1985)
  • W Jiang et al.

    Rapid detection of ras oncogenes in human tumors: Applications to colon, esophageal, and gastric cancer

    Oncogene

    (1989)
  • K Tadokoro et al.

    Polymerase chain reaction (PCR) for detection of Apa1 polymorphism at the insulin like growth factor II gene (IGF2)

    Nucleic Acids Res

    (1991)
  • J Byrne et al.

    New Taql polymorphism in the RRM1 gene

    Nucleic Acids Res

    (1991)
There are more references available in the full text version of this article.

This work was supported by the Anti-Cancer Foundation of the University of South Australia.

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