Elsevier

Journal of Neuroimmunology

Volume 1, Issue 3, September 1981, Pages 227-237
Journal of Neuroimmunology

Breakdown of the blood-cerebrospinal fluid barrier to immunoglobulin in mice injected intracerebrally with a neurotropic influenza A virus: Post-exposure treatment with monoclonal antibody promotes recovery

https://doi.org/10.1016/0165-5728(81)90027-8Get rights and content

Abstract

Mice may be protected from the invariably fatal consequences of intracerebral (i.c.) inoculation of A/WSN influenza virus by intravenous injection with 0.5 mg of virus-specific monoclonal anti-hemagglutinin antibody given 2 days after i.c. challenge. The integrity of the blood-cerebrospinal fluid (CSF) barrier in such mice has been examined by comparing specific immunoglobulin (Ig) titers in serum and CSF. It seems that the process of virus growth results directly in substantial breakdown of the blood-CSF barrier at some time between 63 and 96 h after i.c. exposure to virus. The exogenously administered, virus-specific monoclonal antibody is not obviously involved either in abrogating the integrity of this physiological barrier system or in promoting inflammation. In fact, higher Ig titers are found in CSF for an antibody that does not bind to the virus. This presumably reflects the fact that virus-infected cells in the central nervous system are adsorbing specific Ig from the CSF.

References (18)

There are more references available in the full text version of this article.

Cited by (20)

  • Inflammation in virus infections

    1993, Seminars in Virology
View all citing articles on Scopus

These experiments were funded by grants from the National Multiple Sclerosis Society and the National Institutes of Health (NS 11036, AI 13989 and AI 14162).

View full text