Trends in Pharmacological Sciences
Species differences in the pharmacology of terminal 5-HT autoreceptors in mammalian brain
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Classification and signaling characteristics of 5-HT receptors: toward the concept of 5-HT receptosomes
2020, Handbook of Behavioral NeuroscienceCitation Excerpt :Thereafter, a receptor having very similar pharmacological properties (except for its low affinity for β-adrenergic antagonists) and the same ability to inhibit 5-HT release and cAMP production in those species was described. This receptor thought to be present only in some species such as pig and human (Hoyer & Middlemiss, 1989; Schoeffter & Hoyer, 1989) was called 5-HT1D. The cloning of two genes (initially called HT1RDα and HT1RDβ) in human that share very similar sequences and encode receptors with common 5-HT1B/D pharmacology led to the proposal that the 5-HT1B receptor is coded by the HT1RDβ gene, whereas the 5-HT1D receptor is coded by the HT1RDα gene in all species.
Distribution of 5-HT receptors in the central nervous system: an update
2020, Handbook of Behavioral NeuroscienceFast-acting antidepressant activity of ketamine: highlights on brain serotonin, glutamate, and GABA neurotransmission in preclinical studies
2019, Pharmacology and TherapeuticsCitation Excerpt :Rivera-Garcia et al. (2015) (Rivera-Garcia et al., 2015) has therefore reported no effect of WAY100635 (1 mg/kg, i.p.) on ketamine (3 and 10 mg/kg, i.p.) positive effects in the head-twitch response (a serotonin-dependent test) and 5-HT levels in post-mortem rat brain tissue homogenates, indicating that 5-HT1A autoreceptors unlikely play a significant role in ketamine-induced increases in 5-HT neurotransmission. Presynaptic 5-HT1B autoreceptors located at serotonergic nerve terminals are involved in a negative feedback control of 5-HT release (Gothert, Schlicker, Fink, & Classen, 1987; Hoyer & Middlemiss, 1989). In contrast, 5-HT1B heteroreceptors are involved in the regulation of the release of various neurotransmitters, e.g., inhibitory activity on glutamatergic, GABAergic, dopaminergic, noradrenergic and cholinergic neurons (Langlois et al., 1995).
Serotonin receptors nomenclature
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