Species differences in the pharmacology of terminal 5-HT autoreceptors in mammalian brain

https://doi.org/10.1016/0165-6147(89)90159-4Get rights and content

First page preview

First page preview
Click to open first page preview

References (29)

  • D. Hoyer et al.

    Eur.J. Pharmacol.

    (1985)
  • D. Hoyer et al.

    Eur.J. Pharmacol.

    (1985)
  • D. Hoyer et al.

    Brain Res.

    (1986)
  • D. Hoyer et al.

    Neurosci. Lett

    (1988)
  • A. Pazos et al.

    Brain Res.

    (1985)
  • C. Waeber et al.

    Neurosci. Lett.

    (1988)
  • R. Bouhelal et al.

    Eur.J. Pharmacol.

    (1988)
  • D. Hoyer et al.

    Eur.J. Pharmacol.

    (1988)
  • J. Schipper et al.
  • T.J. Feuerstein et al.

    Neuropharmacology

    (1987)
  • T.J. Feuerstein et al.

    Naunyn-Schmiedebergs Arch. Pharmacol.

    (1985)
  • G. Engel

    Naunyn-Schmiedebergs Arch. Pharmacol.

    (1983)
  • D.N. Middlemiss
  • R.E. Heuring et al.

    J. Neurosci.

    (1987)
  • Cited by (339)

    • Classification and signaling characteristics of 5-HT receptors: toward the concept of 5-HT receptosomes

      2020, Handbook of Behavioral Neuroscience
      Citation Excerpt :

      Thereafter, a receptor having very similar pharmacological properties (except for its low affinity for β-adrenergic antagonists) and the same ability to inhibit 5-HT release and cAMP production in those species was described. This receptor thought to be present only in some species such as pig and human (Hoyer & Middlemiss, 1989; Schoeffter & Hoyer, 1989) was called 5-HT1D. The cloning of two genes (initially called HT1RDα and HT1RDβ) in human that share very similar sequences and encode receptors with common 5-HT1B/D pharmacology led to the proposal that the 5-HT1B receptor is coded by the HT1RDβ gene, whereas the 5-HT1D receptor is coded by the HT1RDα gene in all species.

    • Fast-acting antidepressant activity of ketamine: highlights on brain serotonin, glutamate, and GABA neurotransmission in preclinical studies

      2019, Pharmacology and Therapeutics
      Citation Excerpt :

      Rivera-Garcia et al. (2015) (Rivera-Garcia et al., 2015) has therefore reported no effect of WAY100635 (1 mg/kg, i.p.) on ketamine (3 and 10 mg/kg, i.p.) positive effects in the head-twitch response (a serotonin-dependent test) and 5-HT levels in post-mortem rat brain tissue homogenates, indicating that 5-HT1A autoreceptors unlikely play a significant role in ketamine-induced increases in 5-HT neurotransmission. Presynaptic 5-HT1B autoreceptors located at serotonergic nerve terminals are involved in a negative feedback control of 5-HT release (Gothert, Schlicker, Fink, & Classen, 1987; Hoyer & Middlemiss, 1989). In contrast, 5-HT1B heteroreceptors are involved in the regulation of the release of various neurotransmitters, e.g., inhibitory activity on glutamatergic, GABAergic, dopaminergic, noradrenergic and cholinergic neurons (Langlois et al., 1995).

    • Serotonin receptors nomenclature

      2019, The Serotonin System: History, Neuropharmacology, and Pathology
    View all citing articles on Scopus
    View full text