The activity of (S)-1-[(3-hydroxy-2-phosphonyl methoxy) propyl] cytosine (HPMPC) against equine herpesvirus-1 (EHV-1) in cell cultures, mice and horses
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2020, Antiviral ResearchCitation Excerpt :E. Derm cells and EEK cells are both equine cell lines and most adapted to identify new antiviral compounds in equid species, especially EEK that was derived from a horse foetus that is one of the target of EHV-1 (Léon et al., 2008; Smith et al., 2010). Even though RK13 cells are not equine cells, they have been most frequently used in EHV1 antiviral studies (Azab et al., 2010; de la Fuente et al., 1992; Gibson, 1992; Rollinson, 1987). All compounds except aciclovir and gemcitabine showed some consistent antiviral activity in the three different cell lines.
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