Molecular karyotype of five species of Leishmania and analysis of gene locations and chromosomal rearrangements
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Amplified fragment length polymorphism (AFLP) analysis is useful for distinguishing Leishmania species of visceral and cutaneous forms
2010, Acta TropicaCitation Excerpt :Data from AFLP studies support that species causing cutaneous and visceral disease have diverged primarily due to mutations, insertions, deletions, and/or other genetic rearrangements. However, it has been shown by (Samaras and Spithill, 1987) that DNA sequences are rearranged during speciation in Leishmania. Parasite genome plasticity has been hypothesized to play a driving role in parasite speciation.
Leishmania (Viannia) braziliensis transfectants overexpressing the miniexon gene lose virulence in vivo
2009, Parasitology InternationalCitation Excerpt :Iovannisci and Beverley associated expansion of the miniexon array with growth advantage of promastigotes in vitro [13]. Samaras and Spithill showed that an avirulent L. (L.) major clone presented a larger chromosome 2 and suggested that its size polymorphism could be due to an expansion of the miniexon locus [11]. On the other hand, a few L. (L.) major virulent lines, such as Friedlin and LV39, bear an amplified version of one or both alleles of chromosome 2 [14].
Shotgun optical mapping of the entire Leishmania major Friedlin genome
2004, Molecular and Biochemical ParasitologyDevelopmental regulation of heat shock protein 83 in Leishmania: 3′ processing and mRNA stability control transcript abundance, and translation is directed by a determinant in the 3′-untranslated region
2001, Journal of Biological ChemistryCitation Excerpt :Nco I sites are found 1.2 and 0.8 kb upstream and downstream from the first and last gene copies, respectively. Southern analysis of L. amazonensis pulse field gel electrophoresis blots revealed a single 67-kb fragment that hybridized with the HSP83 probe (Fig. 1), confirming the presence of a single HSP83 genome cluster, mapped to chromosome 28 of L. major (23). Based on the size of the repeat unit (3,580 bp (20)), the 67-kb fragment contains 18 tandem repeats of the HSP83 gene.
Chromosome structure and sequence organization between pathogenic and non-pathogenic Leishmania spp
2000, Molecular and Biochemical Parasitology