The thymus
The thymic microenvironment

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Abstract

The thymus has been recognized as a site of primary immune function for more than three decades and yet, despite intense research, many of the central questions regarding its function in T-lymphocyte maturation have remained unanswered. Current cellular and molecular analytical techniques are finally proving to be sophisticated enough to define the cells which comprise the thymic framework and dissect their complex interactions with developing thymocytes. In a series of articles over the coming months Immunology Today will be investigating the complex interrelationship between the thymic microenvironment and the developing T cell. As a foundation for these, Richard Boyd and colleagues provide a detailed overview of the basic thymic components, backed up by an extensive bibliography and full colour poster. The latest research trends are then summarized by Donald Palmer, Adrian Hayday and Michael Owen, followed by an examination of the mutual interdependence of thymic stroma and thymocyte by Mary Ritter and Richard Boyd.

References (448)

  • P.M. Appasamy et al.

    Cell. Immunol.

    (1991)
  • R.L. Boyd et al.

    Immunol. Today

    (1991)
  • R.L. Boyd et al.

    J. Autoimmunity

    (1991)
  • A.S. Chan

    Poultry Sci.

    (1986)
  • A.S. Chan

    Exp. Pathol.

    (1987)
  • A.G. Clarke et al.

    Immunol. Today

    (1986)
  • S. Cohen-Kaminsky et al.

    Cell. Immunol.

    (1991)
  • M. Crowley et al.

    Cell. Immunol.

    (1989)
  • A.H. Dalloul et al.

    Blood

    (1991)
  • M. Dardenne et al.

    Cell. Immunol.

    (1986)
  • M.P. Defresne et al.

    Leuk. Res.

    (1986)
  • A.M. Duijvestijn et al.

    Dev. Comp. Immunol.

    (1984)
  • S. Ezine et al.

    Mol. Immunol.

    (1992)
  • B. Adkins et al.

    J. Immunol.

    (1988)
  • B. Adkins et al.

    Immunogenetics

    (1988)
  • R. Agger et al.

    Int. Rev. Immunol.

    (1990)
  • M. Aita et al.

    Histochemistry

    (1984)
  • M. Aita et al.

    Cell. Mol. Biol.

    (1989)
  • G. Anderson et al.

    Nature

    (1993)
  • J.L. Andreu-Sanchez et al.

    Eur. J. Immunol.

    (1990)
  • P. Andrews et al.

    Eur. J. Immunol.

    (1985)
  • P. Andrews et al.

    Eur. J. Immunol.

    (1985)
  • C. Arvadin et al.

    Eur. J. Immunol.

    (1992)
  • C. Ardavin et al.

    Nature

    (1993)
  • J. Aubry et al.

    Thymus

    (1990)
  • J.M. Austyn

    Immunology

    (1987)
  • Z.K. Ballas et al.

    J. Immunol.

    (1987)
  • A.N. Barclay et al.

    J. Exp. Med.

    (1981)
  • T.S. Barry et al.

    J. Exp. Med.

    (1991)
  • H. Barthélémy et al.

    Lab. Invest.

    (1986)
  • B. Bauvois et al.

    J. Immunol.

    (1989)
  • L.V. Beletskaya et al.

    Scand. J. Immunol.

    (1980)
  • D.I. Beller et al.

    J. Immunol.

    (1977)
  • D.I. Beller et al.

    J. Immunol.

    (1978)
  • D.I. Beller et al.

    J. Immunol.

    (1980)
  • M. Belo et al.

    Int. Immunol.

    (1989)
  • S. Berrih et al.

    J. Histochem. Cytochem.

    (1985)
  • M. Bix et al.

    Nature

    (1992)
  • M. Bofill et al.

    Am. J. Pathol.

    (1985)
  • J. Boniyer et al.

    Thymus

    (1981)
  • J.Y. Bonnefoy et al.

    Thymus

    (1984)
  • F.M. Botteri et al.

    Mol. Cell. Biol.

    (1987)
  • R.I. Boyd et al.

    J. Immunol.

    (1984)
  • R.L. Boyd et al.

    Int. Arch. Allergy Appl. Immunol.

    (1977)
  • R.L. Boyd et al.

    Dev. Immunol.

    (1992)
  • M. Breel et al.

    Eur. J. Immunol.

    (1987)
  • R. Brelinska et al.

    Cell Tiss. Res.

    (1986)
  • R. Brelinska et al.

    Cell Tiss. Res.

    (1985)
  • P. Brekelmans et al.

    Semin. Immunol.

    (1990)
  • K.G.M. Brockbank et al.

    Thymus

    (1987)

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