Research reportA comparative autoradiographic study of 5-HT1D binding sites in human and guinea-pig brain using different radioligands
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Cited by (45)
Distribution of 5-HT receptors in the central nervous system: an update
2020, Handbook of Behavioral NeuroscienceCitation Excerpt :However, once both 5-HT1B and 5-HT1D receptors were acknowledged to exist in the different mammalian species, it was still not easy to determine the actual distribution of 5-HT1D receptors due both to the fact that their density (compared to that of 5-HT1B) is quite low and to the lack of radioligands that discriminate clearly between 5-HT1B and 5-HT1D receptors. By using [125I]-GTI as a radioligand in the presence of CP93129 to block its binding to 5-HT1B receptors, Bruinvels and colleagues (Bruinvels, Landwehrmeyer, Probst, Palacios, & Hoyer, 1994b) described the presence of comparatively low densities of 5-HT1D binding sites in the guinea pig globus pallidus, ventral pallidum, caudate-putamen, subthalamic nucleus, entopeduncular nucleus, substantia nigra, nuclei of the (normal and accessory) optic tract, different nuclei of the geniculate body and frontoparietal cortex. All these structures contain much higher densities of 5-HT1B receptors.
The serotonergic system in Parkinson's disease
2011, Progress in NeurobiologyCitation Excerpt :An in situ hybridisation (ISH) study found that 5-HT1Dα (i.e. 5-HT1D) receptor mRNA is very scarce in the rat brain, with moderately abundant levels in the striatum (Bruinvels et al., 1994a). Several autoradiographic receptor binding studies assessing the distribution of 5-HT1D receptors were performed in the rat and human brains (Barone et al., 1994; Bruinvels et al., 1993, 1994b; del Olmo et al., 1996; Herrick-Davis and Titeler, 1988; Miller and Teitler, 1992; Pascual et al., 1996; Waeber et al., 1988a). However, because non-selective radioligands were used or 5-HT1Dβ (i.e. 5-HT1B) receptors were being measured, these results will not be discussed further.
Molecular biology of 5-HT receptors
2008, Behavioural Brain ResearchLigands for the investigation of 5-HT autoreceptor function
2001, Brain Research BulletinAutoradiographic mapping of 5-HT<inf>1B</inf> and 5-HT<inf>1D</inf> receptors in the post mortem human brain using [<sup>3</sup>H]GR 125743
2001, Brain ResearchCitation Excerpt :First, the 5-HT1B mRNA shows a widespread distribution, with highest levels in the nucleus caudatus and the putamen [29], while the 5-HT1D receptor mRNA has only been detected in the CA3 field of Ammon’s horn in the human brain [38]. Second, the 5-HT1B/1D receptor selective radioligand [125I]GTI labels a homogenous population of 5-HT1B/1D receptors in the basal ganglia and the cerebral cortex [4,8]. Third, in more recent studies, using the preferential 5-HT2A antagonist ketanserin, which shows about 60- to 70-fold selectivity for human 5-HT1D compared to 5-HT1B receptors [32,49] in combination with 5-HT1B/1D receptor agonist radioligands, only a limited amount of 5-HT1D receptors could be discriminated [5,10].
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Present address: Neurology Service, Massachusetts General Hospital, Fruit Street, Boston, MA 02114, USA.
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Present address: Departemento de Neuroquìmica, CID, CSIC, Jordi Girona 18-26, Barcelona 08034, Spain.