(D) Routes of delivery: Case studies: (3) Mechanistic insights to buccal delivery of proteinaceous substances

doi:10.1016/0169-409X(92)90003-9

Advanced Drug Delivery Reviews

Volume 8, Issues 2–3, March–June 1992, Pages 197-236

https://doi.org/10.1016/0169-409X(92)90003-9 Get rights and content

Abstract

There are sufficient in vivo demonstrations that the buccal delivery of peptides is a potential alternative route of administration. Passage across the squamous epithelium occurs by simultaneous passive diffusion and metabolism. The inefficient permeability properties of peptides contribute to their low systemic bioavailability, thus requiring that peptides must be highly potent to exhibit biological activity. This review emphasizes: [1] the nature of the physical, anatomical and enzymatic barriers; [2] the interplay of biophysical factors and physicochemical properties of peptides governing transport mechanisms wherein non-peptide compounds are used as standards; [3] the roles of absorption promoters; and [4] gaps in our current approaches and understanding of peptide transport.

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(D) Routes of delivery: Case studies: (3) Mechanistic insights to buccal delivery of proteinaceous substances

Abstract

J. Invest. Derm.

Comp. Biochem. Physiol.

Biochem. Biophys. Res. Commun.

Int. J. Pharm.

J. Pharm. Sci.

Int. J. Pharm.

Adv. Drug Del. Rev.

J. Pharm. Sci.

J. Pharm. Sci.

J. Controlled Rel.

J. Controlled Rel.

Int. J. Pharm.

Arch. Oral Biol.

J. Invest. Dermatol.

Int. J. Pharm.

Quantitative electron microscopic analysis of the stratified epithelium of normal human buccal mucosa

Cell Tissue Res.

Differentiation in normal human buccal mucosa

J. Anat.

The mucus barrier and absorption through the oral mucosa

J. Dent. Res.

The lipid composition of porcine epidermis and oral epithelium

Arch. Oral Biol.

Vascularization of the buccal cavity

Arch. Anat. Hist. Embryol.

The vascular system and blood supply

Aminopeptidase characteristics of human buccal mucosa

Enzymologia

Enkephalin hydrolysis in homogenates of various absorptive mucosae in the albino rabbit: similarities in rates and involvement of aminopeptidases

Life Sci.

Aminopeptidase activity in human buccal epithelium and primary cultures of hamster buccal epithelium

Pharm. Res.

Reversed-phase high-performance liquid chromatographic analysis of oligoglycines

Pharm. Res.

Stability of human calcitonin in the supernatant of the rat oral mucosal homogenate

Yakuzaigaku

Characterization of transport pathways of thyrotropin releasing hormone in rabbit buccal mucosa

Comparative study of intravenous, nasal, oral and buccal TRH administration among healthy subjects

J. Endocrinol. Invest.

Transmucosal absorption of small peptide drugs

Pharm. Int. (March)

Absorption of amino acids from human buccal cavity

Biochem. Soc. Trans.

Absorption of sugars from the human buccal cavity

Clin. Sci. Mol. Med.

Permeability of the oral mucosa

Comparison of the absorptive properties of the human buccal mucosa and everted sac of rat small intestine in relation to drug-induced malabsorption

J. Physiol.