Monoclonal antibodies to drugs — digoxin

https://doi.org/10.1016/0192-0561(83)90014-0Get rights and content

Abstract

A number of monoclonal antibodies to digoxin, two of which have been further characterized, were produced by somatic cell fusion. No cross reactivity with chemically related drugs was detected. Preliminary in vivo studies showed altered digoxin pharmacokinetics in antibody treated mice. These monoclonal antibodies could be used for a standardized radioimmunoassay and in the treatment of digoxin toxicity.

References (17)

  • B.E. Bang et al.

    Studies of monoclonal and polyclonal anti-digoxin antibodies for serum digoxin radioimmunoassay

    Scand. J. clin. Lab. Invest.

    (1981)
  • V.P. Butler et al.

    Digoxin specific antibodies

    PNAS

    (1967)
  • H.M. Chandler et al.

    An investigation of the use of urease-antibody conjugates in enzyme immunoassays

    J. immun. Meth.

    (1982)
  • W.A. Colburn

    Specific antibodies and Fab fragments to alter the pharmacokinetics and revers the pharmacologic/toxicologic effects of drugs

    Drug Metab. Rev.

    (1980)
  • T. Hess et al.

    The effectiveness of digoxin-specific F(ab)2 antibody fragments in the treatment of digitoxin poisoning: experimental investigations in the cat

    Eur. J. clin. Invest.

    (1980)
  • P.M. Hogarth et al.

    Monoclonal antibodies to murine cell surface antigens. I. Lyt-1.11

    J. Immun.

    (1980)
  • T.J. Houghen et al.

    Effect of inotropic and arrythmogenic digoxin doses and of digoxin-specific antibody on mycordial monovalent cation transport in the dog

    Circ. Res.

    (1979)
  • G. Kohler et al.

    Continuous cultures of fused cells secreting antibody of predefined specificity

    Nature

    (1975)
There are more references available in the full text version of this article.

Cited by (8)

View all citing articles on Scopus
View full text