Elsevier

Neurobiology of Aging

Volume 7, Issue 6, November–December 1986, Pages 441-443
Neurobiology of Aging

Commentary
Amyloid proteins in Alzheimer's disease

https://doi.org/10.1016/0197-4580(86)90060-6Get rights and content

Abstract

Although a number of controversies have emerged from the increased study of fibrous protein deposits found in Alzheimer's brain tissue, many of the issues can be attributed to various methodological differences of the investigators. Moreover, the interpretations of many findings need to be considered in light of the understated assumptions inherent in various manipulations and methodologies. Although the positions presented by Selkoe can be debated at length, much of the controversy and disagreement currently under discussion can be expected to diminish as the biochemical properties of the amyloid proteins are more clearly defined, and as application of molecular biology techniques help identify precursor molecule(s) and the gene sequence of the abnormal proteins.

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