Altered CD3 chain and cytokine gene expression in tumor infiltrating T lymphocytes during the development of mesothelioma
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Intracavitary Therapeutics for Pleural Malignancies
2013, Clinics in Chest MedicineCitation Excerpt :Immunotherapy has been attempted in MM, despite observations of a significant immunosuppressive tumor microenvironment.20–22 In addition to the tumor’s innate mechanisms of immune evasion, patients with MM have impaired immune systems: abnormal humoral and cell-mediated immunity, abnormal cell-mediated antibody-dependent cellular toxicity, and defective macrophage and natural killer (NK) cell function.22–25 However, high local levels of certain proinflammatory cytokines may be able to overcome the innate immune resistance of MM.
No relationship between tumour infiltrating lymphocytes and overall survival is seen in malignant mesothelioma of the pleura [1]
2002, European Journal of Surgical OncologyChronic immune activation and inflammation in the pathogenesis of AIDS and cancer
2002, Advances in Cancer Research
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