Elsevier

Neuroscience Letters

Volume 68, Issue 1, 11 July 1986, Pages 11-16
Neuroscience Letters

Ionic regulation of the binding of dl-2-amino-7-phosphono-[4,5-3H]heptanoic acid to synaptosome-enriched homogenates of rat cerebral cortex

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Abstract

The ionic requirements of the site labelled by dl-2-amino-7-phosphono-[4,5-3H]heptanoic acid ([3H]dl-2AP7) in synaptosome-enriched homogenates of rat cerebral cortex were examined using radioligand binding methodology. Binding of [3H]dl-2AP7 was increased by calcium and chloride ions by an apparently non-competitive mechanism. The actions of ions on specific binding displayed similarities to the effects of ions on dl-[3H]2-amino-4-phosphonobutyric acid and Cl /Ca2+-dependent l-[3H]glutamate ([3H]Glu) binding sites but were more consistent with the Glu-C binding site.

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