Intrathecal kynurenate reduces arterial pressure, heart rate and baroreceptor-heart rate reflex in conscious rats
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Cited by (27)
Angiotensin 1-7 in the rostro-ventrolateral medulla increases blood pressure and splanchnic sympathetic nerve activity in anesthetized rats
2018, Respiratory Physiology and NeurobiologyCitation Excerpt :The C1 adrenergic cell group is thought to be the primary source of innervation of the IML from the RVLM, but this is an area of contention (Lipski et al., 1995; Ruggiero et al., 1994; Schreihofer and Guyenet, 1997). There are catecholamines released at the spine (Head and Howe, 1987; Sevigny et al., 2008); however the principle excitatory neurotransmitter secreted by all RVLM vasomotor cells at the IML is glutamate (Bazil and Gordon, 1993; Llewellyn-Smith et al., 1998; Verberne et al., 1990). Since the 1970s, there has been increasing interest in the role of angiotensin peptides in the central nervous system (CNS) and central regulation of blood pressure and sympathetic nerve activity.
Perifornical hypothalamic pathway to the adrenal gland: Role for glutamatergic transmission in the glucose counter-regulatory response
2017, Autonomic Neuroscience: Basic and ClinicalCitation Excerpt :The atlanto-occipital membrane was exposed, a fine polyethylene cannula (SP-8, O.D 0.5 mm, ID 0.2 mm) filled with artificial cerebrospinal fluid (aCSF) was inserted through a small opening in the dura mater, and its tip was positioned at the end of the T9–T10 thoracic vertebra. Kynurenic acid (KYN) (0.5 μmol in 10 μl) or aCSF mixed with fluorescent latex microspheres was slowly administered followed by a 10 μl flush with aCSF (Verberne et al., 1990). The effect of intrathecal KYN or vehicle on the ASNA responses to RVLM stimulation was tested.
Glutamate and GABA content of calbindin-immunoreactive nerve terminals in the rat intermediolateral cell column
2002, Autonomic Neuroscience: Basic and ClinicalIntraspinal amino acid neurotransmitter activities are involved in the generation of rhythmic sympathetic nerve discharge in newborn rat spinal cord
2001, Brain ResearchCitation Excerpt :These amino acid transmitter activities may either stimulate or inhibit SPNs to fine-tune SND. One source of the glutamatergic inputs to SPNs has been found to convey the sympathoexcitatory message originating from the brainstem [14,42,46]. Another source of glutamatergic inputs to SPNs seems to locate within the spinal cord.
Brain concentrations of kynurenic acid after a systemic neuroprotective dose in the gerbil model of global ischemia
1999, Progress in Neuro-Psychopharmacology and Biological Psychiatry
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Present address: Dept. of Pharmacology, University of Limburg, P.O. Box 616, 6200 MD Maastricht, The Netherlands.