An increase in the growth of hair associated with hyperinnervation of the underlying vessels in rabbit skin
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Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells
2020, CellCitation Excerpt :HFSCs in the bulge and hair germ remain quiescent throughout most hair cycles but become proliferative transiently at anagen onset to produce their transit-amplifying progeny—the matrix, which then undergoes massive proliferation and differentiation to fuel the growth of new hair (Greco et al., 2009; Hsu et al., 2014b; Lay et al., 2016; Rompolas et al., 2013; Wang et al., 2016; Zhang and Hsu, 2017; Zhang et al., 2009). It is known that loss of sympathetic innervation is associated with defects in hair growth in diverse organisms (Asada-Kubota, 1995; Botchkarev et al., 1999; Crowe et al., 1993; Kobayasi et al., 1958; Kong et al., 2015–2016; Peters et al., 1999). In addition, adrenergic agonists promote anagen hair follicle growth in cultured skin explants, and external light stimulates hair growth via the sympathetic nervous system (Botchkarev et al., 1999; Fan et al., 2018).
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