An increase in the growth of hair associated with hyperinnervation of the underlying vessels in rabbit skin

doi:10.1016/0304-3940(93)90151-A

Neuroscience Letters

Volume 161, Issue 1, 14 October 1993, Pages 105-108

https://doi.org/10.1016/0304-3940(93)90151-A Get rights and content

Abstract

The localization of sympathetic nerves was studied histochemically in specimens of abdominal free flaps or revascularized graft and anastomosed epigastric arteries (i.e. the cut epigastric artery was resutured) from the operated and contralateral sides of rabbits, compared to controls. In the abdominal skin from control animals, noradrenaline-containing nerves were seen around blood vessels, hair follicles, sweat glands and dermis. In the free flaps, no noradrenaline-containing nerves were present after day 7. However, on the contralateral side, there was an increase in the density of these nerves by day 30, compared with controls. In the epigastric artery, noradrenaline-containing nerves were confined to the adventitial-medial border in control animals and were absent from the anastomosed epigastric arteries, but on the contralateral side they penetrated a third of the medial wall by day 15. Concomitantly, there was excessive growth of hair on the contralateral side. Understanding of the mechanism involved may be of importance in solving the problems associated with hair loss.

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This study examines the hypothesis that neural factors influence the growth of rat vibrissae. We divided the vibrissae in rows α-δ, 1 and 2 and examined their regrowth during the first complete growth period in normal and nerve-lesioned rats. The lesions used were denervation through neonatal capsaicin treatment, surgical sympathecomy in adult rats, neurectomy of the mandibular and buccal branches of the facial nerve in adult rats or division of the infraorbital nerve in adult rats. Normal vibrissae developed a length of 51.1 mm and a diameter of 178 μm (row α-δ), 44.1 mm and 181 μm (row 1) and 33.2 mm and 165 μm (row 2). In all experimental groups the examined vibrissae developed a normal final length and proximal diameter. This indicates that local nerves do not influence vibrissal growth to any major extent.
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An increase in the growth of hair associated with hyperinnervation of the underlying vessels in rabbit skin

Abstract

J. Auton. Nerv. Syst.

J. Invest. Dermatol.

The return of sensation of transplant skin

Surg. Gynecol. Obstet.

Compensatory changes in contralateral sympathetic neurones of the superior cervical ganglion and their terminals in the pineal gland following unilateral ganglionectomy

J. Neurosci.

Innervation of skin grafts.

Surg. Gynec. Obstet.

The regeneration of adrenergic nerves in a free microvascular groin flap in the rat

Scand. J. Plast. Reconstr. Surg.

The nerve growth factor 35 years later

Science

Biological properties of a nerve growth promoting protein and its antiserum