Comparative study on the antibacterial activity of phytochemical flavanones against methicillin-resistant Staphylococcus aureus

doi:10.1016/0378-8741(96)85514-0

Journal of Ethnopharmacology

Volume 50, Issue 1, January 1996, Pages 27-34

https://doi.org/10.1016/0378-8741(96)85514-0 Get rights and content

Abstract

Differently substituted flavanones were isolated from Leguminosae and their antibacterial activity was comparatively studied against methicillin-resistant Staphylococcus aureus (MRSA). The minimum inhibitory concentrations (MICs) of phytochemical flavanones to clinical isolates of MRSA were determined by a serial agar dilution method. The structure-activity relationship has indicated that 2′,4′- or 2′,6′-dihydroxylation of the B ring and 5,7-dihydroxylation of the A ring in the flavanone structure are important for significant anti-MRSA activity and that substitution with a certain aliphatic group at the 6- or 8-position also enhances the activity. Among the thirteen flavanones tested, tetrahydroxyflavanones with these structural characteristics isolated from Sophora exigua and Echinosophora koreensis showed intensive activity to inhibit the growth of all MRSA strains at 3.13-6.25 μg/ml. The present hydroxyflavanones would be useful in the phytotherapeutic strategy against MRSA infections.

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Research paperComparative study on the antibacterial activity of phytochemical flavanones against methicillin-resistant Staphylococcus aureus

Abstract

Tetrahedron

Journal of Ethnopharmacology

Biochemical Pharmacology

Phytochemistry

Phytochemistry

Phytochemistry

Phytochemistry

Archives of Biochemistry and Biophysics

Phytochemistry

Lancet

American Journal of Medicine

Phytochemistry

Journal of Hospital Infection

Vancomycin ototoxicity and nephrotoxicity: a review

Medical Toxicology

Methicillin-resistant Staphylococcus aureus

New England Journal of Medicine

Vancomycin treatment of bacteremia caused by oxacillin-resistant Staphylococcus aureus: comparison with β-lactam antibiotic treatment of bacteremia caused by oxacillin-sensitive Staphylococcus aureus

Journal of Infectious Diseases

Microbiological properties of protoanemonin isolated from Ranunculus bulbosus

Phytotherapy Research

Research paper
Comparative study on the antibacterial activity of phytochemical flavanones against methicillin-resistant Staphylococcus aureus