technical noteThe preparation of high specific activity copper-64 for medical diagnosis
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Cited by (35)
Selective separation of Cu from large excess of Zn using a microfluidic platform
2021, Chemical Engineering and Processing - Process IntensificationCitation Excerpt :However, this would require development of a fast and reliable method for efficient separation of no carrier- added (NCA) 64Cu from bulk quantity of irradiated Zn target. In the past, several methods based on ion-exchange [8–10], solvent extraction [11] and electrochemical separation [12] have been reported for separation of copper radioisotopes from irradiated Zn target. However, most of these methods are slow and cumbersome and are not amenable for use in a hot cell facility.
<sup>64</sup>Cu enrichment using the Szilard-Chalmers effect – The influence of γ-dose
2020, Applied Radiation and IsotopesCitation Excerpt :Moreover, as natural Cu contains 69.18% 63Cu (Laboratory, 2000), using enriched targets only allows for a factor of maximum 1.5 increase in SA. In 1986 E.L. Hetherington et al. (1986) reported that they could achieve specific activities up to 40 TBq/g Cu using 250 mg Cu(II)-phthalocyanine targets utilising the Szilard-Chalmers effect for an irradiation of 12 h with a neutron flux of 5*1017 n/m2s. Longer irradiations resulted in lower specific activities.
The atomic nucleus, nuclear radiation, and the interaction of radiation with matter
2020, Handbook of Radioactivity Analysis: Volume 1: Radiation Physics and Detectors<sup>64</sup>Cu, a powerful positron emitter for immunoimaging and theranostic: Production via <sup>nat</sup>ZnO and <sup>nat</sup>ZnO-NPs
2018, Applied Radiation and IsotopesCitation Excerpt :64Cu can be produced via 64Ni(p,n)64Cu reaction as a suitable reaction for reaching high production yields by cyclotron up to about 18 MeV, whereas the disadvantage of this reaction is the high costs of enriched 64Ni (Thieme et al., 2012; Le et al., 2009). 64Cu can also be produced in a nuclear reactor with 64Zn(n,p)64Cu and natZn(n,p)64Cu reactions (Johnsen et al., 2015; Bokhari et al., 2010; Cohen et al., 2016; Uddin et al., 2014, 2013; Hassanein et al., 2006; Spahn et al., 2004; Van Elteren et al., 1999; Mushtaq et al., 1990; Fritze, 1964; Hetherington et al., 1986). The advantages of these reactions are low production costs, reasonable cross section and convenience separation 64Cu from target with no radionuclide impurities except 67Cu with minor activity.
Automation of <sup>64</sup>Cu production at Turku PET Centre
2014, Applied Radiation and IsotopesRadiation Physics and Radionuclide Decay
2012, Handbook of Radioactivity Analysis