Neuron
ArticleHeteropolymeric potassium channels expressed in xenopus oocytes from cloned subunits
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Ligand modulation of KCNQ-encoded (K<inf>V</inf>7) potassium channels in the heart and nervous system
2021, European Journal of PharmacologyArthropod toxins acting on neuronal potassium channels
2017, NeuropharmacologyCitation Excerpt :A complete Kv channel can be formed by identical subunits (homotetramer) or by distinct subunits (heterotetramers), such those formed by subunits of the same family (in the case of the Kv1, Kv7 and Kv10 families). For example, Kv1.1 can heteropolymerize with Kv1.2 and Kv1.5 but not with Kv4 channels (Christie et al., 1990). The Kv channels are the most abundant.
Distinctive role of K<inf>V</inf>1.1 subunit in the biology and functions of low threshold K<sup>+</sup> channels with implications for neurological disease
2016, Pharmacology and TherapeuticsCitation Excerpt :Detailed analysis of the biophysical profiles of KV1 homo-tetramers, in addition to differences in their inactivation types and kinetics (N-, C-type inactivation and non-inactivating delayed rectifier currents) (Hoshi et al., 1990; Ashcroft, 2000; Hoshi & Armstrong, 2013), also revealed subtle but important variations in their activation threshold and kinetics (Table 1). Although the physiological significance of these variations between homo-tetramers remain to be established, under certain conditions they are likely to play a decisive role in regulating neuronal activity and synaptic transmission, given that co-assembly of KV1 subunits in hetero-tetramers yields integral currents with functional characteristics that are somewhat intermediate from their contributing subunits (Akhtar et al., 2002; Christie et al., 1990; Grissmer et al., 1994; Gutman et al., 2005; Hopkins et al., 1994; O. Shamotienko et al., 1999; Stuhmer et al., 1989) (Fig. 3). Importantly, features of KV1.1 such as the especially low activation threshold (KV1.1 V1/2 = −35 mV < KV1.6 V1/2 = −20 mV < KV1.2 V1/2 = 5–27 mV < KV1.4 V1/2 = 22–34 mV) and fastest activation kinetics (KV1.1 τ = 5 ms < KV1.2 τ = 6 ms < KV1.6 τ = 6–8 ms < KV1.4 τ = 16.5 ms) (Grissmer et al., 1994; Cox, 2005; Gutman et al., 2005; Sokolov et al., 2007) would be of critical importance in regulating neuronal excitability and responsiveness to fast depolarizing inputs.
Potassium channels in the central nervous system of the snail, Helix pomatia: Localization and functional characterization
2014, NeuroscienceCitation Excerpt :K+-channels also consist of subunits and in vertebrates the native channel structure is a homomultimer. There are evidences that co-expression of two kinetically or pharmacologically distinct K+-channels results in a hybrid behavior of ionic currents (Christie et al., 1990; McCormack et al., 1990). It indicates that heteromultimeric channels possibly contribute to the channel functional diversity.
Functional analysis of missense mutations in Kv8.2 causing cone dystrophy with supernormal rod electroretinogram
2012, Journal of Biological Chemistry