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Mitotic mechanisms: an alternative view

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Abstract

The mechanisms that control spindle structure and move chromosomes remain as mysterious as ever. Using the diatom as a model spindle type, several interesting and counter-intuitive possibilities have emerged. For example, there may not be an anaphase motor and a primary energy-requiring (force-producing) mechanism may actually move chromosomes away from the pole. Force may be a primary factor controlling microtubule assembly disassembly.

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      This has prompted some to question whether mitotic spindles act as “a sponge” during the isolation procedure and has led to concerns about the physiological relevance of many components that copurify with the mitotic apparatus (Wells, 2001). Nonetheless, when isolated spindles are extracted with calcium and/or shifted to low temperatures, a “spindle remnant” can be isolated that retains spindle‐like morphology despite the absence of microtubules (Leslie et al., 1987; Pickett‐Heaps, 1986; Rebhun and Palazzo, 1988; Wein et al., 1998). Rebhun and Palazzo (1988) reported that Ca2+‐extracted spindles contained a ∼55 kDa polypeptide with an amino acid composition similar to intermediate filament proteins.

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