Trends in Biochemical Sciences
Special issueSubstrate and pseudosubstrate interactions with protein kinases: determinants of specificity
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DCLK1 autoinhibition and activation in tumorigenesis
2022, InnovationCitation Excerpt :An AID maintains a kinase in the inactive state, and activation occurs when this domain is sequestered by a specific activator protein. For example, activators represented by Ca2+/calmodulin in myosin light chain kinases (MLCKs) and CaMKs51 and Ca2+/Sl00 in twitchin43 have been proposed to interact with the inhibitory segment, release autoinhibition, and allow catalytic function. Although the first helix (R1) in the DCLK1 AID is characteristic of a Ca2+/calmodulin-binding motif and the AID-binding mode is structurally similar to twitchin, we failed to detect DCLK1 activation by Ca2+/calmodulin or Ca2+/S100.
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