Chapter 22 - Imaging the Morphology and Structure of Apolipoprotein Amyloid Fibrils
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Unique insights to intrinsically disordered proteins provided by ion mobility mass spectrometry
2018, Current Opinion in Chemical BiologyCitation Excerpt :Use of a toy model [39••] showed that α-synuclein explored approximately 90% of the collision cross section space available to it whilst ApoC-II only explored around 30%. An explanation for this anomalous result is that ApoC-II restructures as it desolvates, perhaps towards a helix rich structure akin to that in which it is found in membranes [53], or more likely to a well self-solvated compact globular state. Unlike structured proteins which can be characterised by wide CSDs when sprayed from solutions at low or high pH, ApoC-II shows little variation, which is also explained by restructuring upon transfer.
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