Inflammation and Immunity in Depression

Inflammation and Immunity in Depression

Basic Science and Clinical Applications
2018, Pages 539-548
Inflammation and Immunity in Depression

Chapter 31 - Modulation of Inflammation by Antidepressants

https://doi.org/10.1016/B978-0-12-811073-7.00031-3Get rights and content

Abstract

Antidepressants have been reported to modify immune functions, and results suggest that several antidepressants may have the ability to reduce pro-inflammatory factors measured in peripheral blood. Particularly, C-reactive protein, tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 have been the target proteins that show a reduction in peripheral blood levels in antidepressant trials. In addition, the effects of antidepressants on the factors of the adaptive immune system have been observed but have been less systematically investigated with inconclusive results. Since these results suggest that both the innate and possibly the adaptive immune system may be mechanistically involved in mediating antidepressant effects in depression, future studies should broadly consider immune factors as mediators of antidepressant effects and their specific contribution to a neuroimmune interplay in depression that deserves more in-depth and rigorous clinical and preclinical research.

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