Nanotechnology for Oral Drug Delivery

Nanotechnology for Oral Drug Delivery

From Concept to Applications
2020, Pages 317-357
Nanotechnology for Oral Drug Delivery

Chapter 11 - Batch and microfluidic reactors in the synthesis of enteric drug carriers

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Abstract

The design and development of drug delivery vectors are complex, multi-step processes that require extensive efforts for chemical characterization, mass production, toxicity testing, and preclinical and clinical trials. When using conventional batch-type discontinuous reactors in their fabrication, the scarce control on mixing conditions required to produce drug loaded particles, especially as the reactor volume is increased, leads to polydisperse distributions and batch-to-batch variations.

Microfluidics have been applied in drug development and manufacturing in order to overcome main limitations of conventional batch-type reactors. Herein, we introduce the field of oral drug delivery and their associated drug carriers manufactured using microfluidics. Examples of pH-dependent and pH-independent drug loaded vectors developed to target specific sites of the intestine are reviewed, as well as different approaches to cross the intestinal lining and reach systemic circulation.

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