CHAPTER 75 - Prevention of Autoimmune Disease: Type 1 Diabetes as a Paradigm
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Type 1 diabetes: Lessons for other autoimmune diseases?
2008, Journal of AutoimmunityCitation Excerpt :Autoimmune diabetes in the NOD mouse shares features with human T1D, including spontaneous occurrence (in contrast to most other rodent autoimmune disease models), polygenic inheritance dominated by the major histocompatibility complex, autoimmunity to (pro)insulin, transfer of disease by bone marrow and a protracted pre-clinical phase. A large body of evidence demonstrates that (pro)insulin plays a pre-eminent role in driving autoimmune β-cell destruction (reviewed in [27,38]), reinforced by the studies showing that mucosally-administered insulin or proinsulin peptide induces regulatory T cells that protect NOD mice against diabetes (reviewed in [38]). So why have trials of oral insulin in individuals with recent-onset T1D, and trials of oral myelin basic protein or oral collagen in MS and rheumatoid arthritis sufferers, respectively, shown no clinical effects?
Autoimmunity and the pathogenesis of type 1 diabetes
2010, Critical Reviews in Clinical Laboratory SciencesVaccination against self to prevent autoimmune disease: The type 1 diabetes model
2008, Immunology and Cell Biology