Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume 1863, Issue 2, February 2017, Pages 585-597
ReviewNrf2 signaling pathway: Pivotal roles in inflammation
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Abbreviations
ARE
antioxidant response element
CBP
cAMP-response-element-binding protein binding protein
COX-2
cyclooxygenase 2
Gclc
glutamate cysteine ligase catalytic subunit
Gclm
glutamate cysteine ligase regulatory subunit
GSH
glutathione
HO-1
heme oxygenase-1
IKKβ
inhibitor of nuclear factor kappa-B kinase
ICAM-1
intercellular adhesion molecule1
IL-17
interleukin 17
IL-6
interleukin 6
JAK
janus kinase
KEAP1
Kelch-like ECH associated protein
LDL
low-density lipoprotein
LPS
lipopolysaccharide
MAPK
mitogen-activated protein kinase
MCP1
monocyte chemoattractant protein-1
MIP2
macrophage inflammatory protein 2
MMP-7
matrix metalloproteinase 7
MMP-9
matrix metalloproteinase 9
NAD(P)H
nicotinamide adenine dinucleotide phosphate
NF-κB
nuclear factor – κB
NRF2
NF-E2 p45-related factor 2
PrxI
peroxiredoxin I
ROS
reactive oxygen species
RXRα
retinoid X receptor alpha
STAT
signal transducers and activators of transcription
TREM1
triggering receptor expressed on myeloid cells 1
Th1
T helper cell 1
Th17
T helper cell 17
TNF-α
tumor necrosis factor α
VCAM-1
vascular cell adhesion molecule 1
Keywords
Nrf2
Keap1
ARE
Inflammation
Oxidative stress
Phytochemical
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