Engineered herbal scaffolds for tissue repair and regeneration: Recent trends and technologies

https://doi.org/10.1016/j.bea.2021.100015Get rights and content
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Highlights

  • Current state-of-the-art in engineered herbal constructs for tissue engineering applications.

  • Delineates the bioactive properties of herbal medicines in relevance to tissue engineering.

  • Highlights material and technology perspectives for herbal construct fabrication.

  • Discussion limited to crude herbal extract-loaded constructs.

Abstract

Engineering constructs with adequate bioactive properties that could support effective repair/ regeneration of damaged tissues is still a persisting challenge. An effective and sustainable approach involving a combination of tissue engineering principles and herbal medicines could address this challenge. This particular domain has witnessed tremendous growth over the past decade. In this review, we provide an overview of engineered herbal constructs for tissue engineering applications. We have highlighted various properties of herbal medicines that are relevant to tissue repair and regeneration. Further, a discussion of different biomaterials, fabrication methods, and current progress made with herbal constructs has been provided. On a concluding note, challenges and outlook for further development and clinical translation of these herbal constructs have also been presented.

Keywords

Tissue engineering
Herbal medicines
Plant extracts
Wound healing
Bone regeneration

Abbreviations

2D
Two-dimensional
3D
Three-dimensional
4D
Four-dimensional
AM
Additive manufacturing
CAD
Computer-aided design
DNA
Deoxyribonucleic acid
FTIR
Fourier transform infrared
GO
Graphene oxide
HUVEC
Human umbilical vein endothelial cell
kV
Kilovolt
MSC
Mesenchymal stem cell
PCL
Polycaprolactone
PDX
Polydioxanone
PEG
Poly(ethylene glycol)
PEGMA
PEG-methyl ether methacrylate
PEO
Polyethylene oxide
PHBV
Poly(hydroxybutyrate-covalerate)
PLA
Polylactic acid
PVA
Polyvinyl alcohol
ROS
Reactive oxygen species
TEM
Transmission electron microscopy
TERM
Tissue engineering and regenerative medicines
VEGF
Vascular endothelial growth factor
β-TCP
β-tricalcium phosphate

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Equal contribution