Archival ReportNeural Correlates of Disturbed Emotion Processing in Borderline Personality Disorder: A Multimodal Meta-Analysis
Section snippets
Study Selection
Studies were identified through a literature search of articles published between 2001 (first neuroimaging study on negative emotion processing in BPD) and June 2014 using the PubMed and Web of Science databases. Keywords used were borderline personality disorder and emotion, valence, or affect and neuroimaging, or fMRI. Reference sections and citations of the articles were cross-checked to identify further articles. Studies were included if 1) patients met diagnostic criteria for BPD according
Meta-Analysis of Functional Brain Abnormalities in BPD
In comparison with HC, patients with BPD showed enhanced activity in a cluster comprising the left amygdala and the left hippocampus, as well as in clusters in the posterior cingulate gyrus and the left middle temporal gyrus (Figure 1). However, findings in the left amygdala/hippocampus region showed significant heterogeneity. Enhanced activations were also found in the left posterior insula and right superior temporal gyrus, but these findings were less robust (cf. Table 1).
Decreased activity
Discussion
The present meta-analysis supports the assumption that structural and functional frontolimbic abnormalities represent a hallmark feature of BPD. In particular, our results demonstrate enhanced activation of the left amygdala along with attenuated activations of the bilateral dlPFC during the processing of negative emotional stimuli in BPD compared with healthy control subjects. Functional differences in frontolimbic brain regions were additionally found to overlap with structural differences in
Acknowledgments and Disclosures
No funding was provided for this project.
We deeply appreciate the help of all researchers who supported this project. In particular, we thank Sabine Herpertz, Anja Kraus, Annegret Krause-Utz, Gin Malhi, Michael Minzenberg, Kristin Prehn, Daniele Radaelli, Knut Schnell, and Moria Smoski for providing additional contrasts or statistical parametric maps from their studies. Their help allowed us to create an exhaustive, quantitative summary of emotion processing in borderline personality disorder.
References (86)
- et al.
Psychosocial impairment and treatment utilization by patients with borderline personality disorder, other personality disorders, mood and anxiety disorders, and a healthy comparison group
Compr Psychiatry
(2007) - et al.
Evidence of abnormal amygdala functioning in borderline personality disorder: A functional MRI study
Biol Psychiatry
(2001) - et al.
Amygdala hyperreactivity in borderline personality disorder: Implications for emotional dysregulation
Biol Psychiatry
(2003) - et al.
Neural correlates of emotion processing in borderline personality disorder
Psychiatry Res
(2009) - et al.
Neuronal correlates of cognitive reappraisal in borderline patients with affective instability
Biol Psychiatry
(2011) - et al.
Potentiated amygdala response to repeated emotional pictures in borderline personality disorder
Biol Psychiatry
(2012) - et al.
Affect regulation and pain in borderline personality disorder: A possible link to the understanding of self-injury
Biol Psychiatry
(2010) - et al.
Neural correlates of impaired emotional discrimination in borderline personality disorder: An fMRI study
Prog Neuropsychopharmacol Biol Psychiatry
(2009) - et al.
Neural correlates of the use of psychological distancing to regulate responses to negative social cues: A study of patients with borderline personality disorder
Biol Psychiatry
(2009) - et al.
Neural correlates of negative emotionality in borderline personality disorder: An activation-likelihood-estimation meta-analysis
Biol Psychiatry
(2013)
A new meta-analytic method for neuroimaging studies that combines reported peak coordinates and statistical parametric maps
Eur Psychiatry
Meta-analysis of neuroimaging data: A comparison of image-based and coordinate-based pooling of studies
Neuroimage
Hippocampal volume in borderline personality disorder with and without comorbid posttraumatic stress disorder: A meta-analysis
Eur Psychiatry
Reduced prefrontal and orbitofrontal gray matter in female adolescents with borderline personality disorder: Is it disorder specific?
Neuroimage
Structural brain abnormalities and suicidal behavior in borderline personality disorder
J Psychiatr Res
Amygdala deactivation as a neural correlate of pain processing in patients with borderline personality disorder and co-occurrent posttraumatic stress disorder
Biol Psychiatry
Fronto-limbic dysfunction in response to facial emotion in borderline personality disorder: an event-related fMRI study
Psychiatry Res
Neural responses to emotional stimuli in comorbid borderline personality disorder and bipolar depression
Psychiatry Res
Processing of autobiographical memory retrieval cues in borderline personality disorder
J Affect Disord
Effects of dialectic-behavioral-therapy on the neural correlates of affective hyperarousal in borderline personality disorder
J Psychiatr Res
Neural correlates of the individual emotional Stroop in borderline personality disorder
Psychoneuroendocrinology
Magnetic resonance imaging in patients with borderline personality disorder: A study of volumetric abnormalities
Psychiatry Res
Structural brain features of borderline personality and bipolar disorders
Psychiatry Res
A voxel-based morphometric MRI study in female patients with borderline personality disorder
Neuroimage
Structural brain abnormalities in borderline personality disorder: A voxel-based morphometry study
Psychiatry Res
Multimodal meta-analysis of structural and functional brain changes in first episode psychosis and the effects of antipsychotic medication
Neurosci Biobehav Rev
Brain effects of antidepressants in major depression: A meta-analysis of emotional processing studies
J Affect Disord
Neural network of cognitive emotion regulation--an ALE meta-analysis and MACM analysis
Neuroimage
Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: Related and independent features
Biol Psychiatry
Mining the posterior cingulate: Segregation between memory and pain components
Neuroimage
A comparison of automated segmentation and manual tracing for quantifying hippocampal and amygdala volumes
Neuroimage
A meta-analysis of structural brain abnormalities in PTSD
Neurosci Biobehav Rev
Limbic scars: Long-term consequences of childhood maltreatment revealed by functional and structural magnetic resonance imaging
Biol Psychiatry
Cognitive and emotional influences in anterior cingulate cortex
Trends Cogn Sci
Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective processing
Cortex
The human cerebellum contributes to motor, emotional and cognitive associative learning. A review
Cortex
Biological parametric mapping: A statistical toolbox for multimodality brain image analysis
Neuroimage
Integrating VBM into the General Linear Model with voxelwise anatomical covariates
Neuroimage
Mechanisms of disturbed emotion processing and social interaction in borderline personality disorder: State of knowledge and research agenda of the German Clinical Research Unit
Borderline Personality Disorder and Emotion Dysregulation
The role of affective instability and impulsivity in predicting future BPD features
J Pers Disord
Are the interpersonal and identity disturbances in the borderline personality disorder criteria linked to the traits of affective instability and impulsivity?
J Pers Disord
State affective instability in borderline personality disorder assessed by ambulatory monitoring
Psychol Med
Influence of emotional distraction on working memory performance in borderline personality disorder
Psychol Med
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