Cancer Cell
Volume 22, Issue 6, 11 December 2012, Pages 737-750
ArticleIdentification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma
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Graphical Abstract
Highlights
► Preneoplastic lesions rarely arise from pancreatic ductal/centroacinar cells ► Acinar cells are the predominant cells of origin for pancreatic preneoplastic lesions ► Initiation of pancreatic cancer depends on acinar induction of the ductal gene Sox9 ► Sox9 synergizes with KrasG12D and injury in acinar-to-ductal cell reprogramming
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These authors contributed equally to this work
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