Cell
Volume 184, Issue 16, 5 August 2021, Pages 4109-4112
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Polyamine: A metabolic compass for T helper cell fate direction

https://doi.org/10.1016/j.cell.2021.07.012Get rights and content
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Interplay between metabolic and epigenetic remodeling may be key to cell fate control. In this issue of Cell, Puleston et al. and Wagner et al. use metabolomic, computational, and genetic approaches to uncover that polyamine metabolism directs T helper cell lineage choices, epigenetic state, and pathogenic potential in inflammation.

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