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Physical illnesses, developmental risk factors and psychiatric diagnoses among subjects at risk of psychosis

Published online by Cambridge University Press:  09 September 2011

J. Korkeila ,
R.K.R. Salokangas ,
M. Heinimaaa ,
T. Svirskis ,
T. Laine ,
S. Ruhrmann ,
H. von Reventlow ,
G. Juckel ,
D. Linszen  and
M. Birchwood
...Show all authors
J. Korkeila*
Affiliation:
Department of Psychiatry, University of Turku, Kunnallissairaalantie 20, 20700Turku, Finland Harjavalta Hospital, Satakunta Health District, Finland
R.K.R. Salokangas
Affiliation:
Department of Psychiatry, University of Turku, Kunnallissairaalantie 20, 20700Turku, Finland Turku University Central Hospital, Finland City of Turku, Finland
M. Heinimaaa
Affiliation:
Department of Psychiatry, University of Turku, Kunnallissairaalantie 20, 20700Turku, Finland Turku University Central Hospital, Finland
T. Svirskis
Affiliation:
City of Turku, Finland Department of Psychiatry, University of Helsinki, Finland Peijas Department of Psychiatry, Helsinki University Central Hospital, Finland
T. Laine
Affiliation:
Department of Psychiatry, University of Turku, Kunnallissairaalantie 20, 20700Turku, Finland
S. Ruhrmann
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
H. von Reventlow
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany LWL-Universitaetsklinik Bochum, Ruhr-Universität Bochum, Bochum, Germany
G. Juckel
Affiliation:
LWL-Universitaetsklinik Bochum, Ruhr-Universität Bochum, Bochum, Germany
D. Linszen
Affiliation:
Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
M. Birchwood
Affiliation:
Early Intervention Service, University of Birmingham, Birmingham, UK
J. Klosterkötter
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
*
⁎Corresponding author. Tel.: +3 582 266 2557; fax: +3 582 266 2528. E-mail address:jyrkor@utu.fi (J. Korkeila).
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Abstract

Background

Subjects with psychoses have significantly increased rates of physical illnesses, but the nature of the relationship remains largely unknown.

Material and methods

The present study is part of the European Prediction of Psychosis Study (EPOS). Data were collected from 245 help-seeking individuals from six European centers (age 16–35) who met criteria for ultra-high risk of psychosis criteria. This paper seeks to investigate self-reported physical ill health and its associations with psychiatric symptoms and disorders, risk factors, and onset of psychosis during 48 months of follow-up.

Results

In multivariate analysis, lifetime panic disorder (OR = 2.43, 95%CI: 1.03–5.73), known complications during pregnancy and delivery (OR = 2.81, 95%CI: 1.10–7.15), female gender (OR = 2.88, 95%CI: 1.16–7.17), family history of psychosis (OR = 3.08, 95%CI: 1.18–8.07), and having a relationship (OR = 3.44, 95%CI: 1.33–8.94) were significantly associated with self-reported physician-diagnosed illness. In the Cox proportional hazard model we found no significant differences between those who had undergone a transition to psychosis and those who had not.

Conclusions

The physical health of patients defined to be at ultra-high risk of psychosis seems to be commonly impaired and associated with female gender, marital status, complications during pregnancy and birth, lifetime panic disorder, and genetic risk of psychosis.

Keywords

Risk of psychosisPhysical illnessDevelopmental risk factor
Type
Original article
Information
European Psychiatry , Volume 28 , Issue 3 , March 2013 , pp. 135 - 140
Copyright
Copyright © European Psychiatric Association 2011

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