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Long-term trajectories of cognitive deficits in schizophrenia: A critical overview

Published online by Cambridge University Press:  28 October 2015

A.B. Shmukler ,
I.Y. Gurovich ,
M. Agius  and
Y. Zaytseva
A.B. Shmukler*
Affiliation:
Moscow Research Institute of Psychiatry, Moscow, Russian Federation
I.Y. Gurovich
Affiliation:
Moscow Research Institute of Psychiatry, Moscow, Russian Federation
M. Agius
Affiliation:
Clare College Cambridge, Cambridge, UK Department of Psychiatry, University of Cambridge, Cambridge, UK East London NHS Foundation Trust, London, UK
Y. Zaytseva
Affiliation:
Moscow Research Institute of Psychiatry, Moscow, Russian Federation National Institute of Mental Health, Klecany, Charles University in Prague, Prague, Czech Republic Department of Psychiatry and Medical Psychology, 3rd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic Human Science Centre and Institute of Medical Psychology, Ludwig-Maximilians Universität, Munich, Germany
*
⁎Corresponding author. Department of Outpatient Psychiatry and Organization of Psychiatric Care, Moscow Research Institute of Psychiatry, Branch of Federal Medical Research Centre of Psychiatry and Narcology named after V.P. Serbsky, Poteshnaya Str., 3, 107076 Moscow, Russian Federation. Tel.: +7 499 162 100 3. E-mail address:ashmukler@yandex.ru (A.B. Shmukler).
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Abstract

Background

Cognitive disturbances are widely pronounced in schizophrenia and schizophrenia spectrum disorders. Whilst cognitive deficits are well established in the prodromal phase and are known to deteriorate at the onset of schizophrenia, there is a certain discrepancy of findings regarding the cognitive alterations over the course of the illness.

Methods

We bring together the results of the longitudinal studies identified through PubMed which have covered more than 3 years follow-up and to reflect on the potential factors, such as sample characteristics and stage of the illness which may contribute to the various trajectories of cognitive changes.

Results

A summary of recent findings comprising the changes of the cognitive functioning in schizophrenia patients along the longitudinal course of the illness is provided. The potential approaches for addressing cognition in the course of schizophrenia are discussed.

Conclusions

Given the existing controversies on the course of cognitive changes in schizophrenia, differentiated approaches specifically focusing on the peculiarities of the clinical features and changes in specific cognitive domains could shed light on the trajectories of cognitive deficits in schizophrenia and spectrum disorders.

Keywords

Cognitive deficitsSchizophreniaTrajectoriesFollow-up
Type
Review
Information
European Psychiatry , Volume 30 , Issue 8 , November 2015 , pp. 1002 - 1010
Copyright
Copyright © European Psychiatric Association 2020

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