ReportThe association between psoriasis, diabetes mellitus, and atherosclerosis in Israel: A case-control study
Section snippets
Methods
The study was designed as a retrospective case-control study using data mining techniques utilizing the MHS database. MHS is the second largest organization for managed care in Israel. MHS covers a population of more than 1,600,000 enrollees. MHS has a comprehensive computerized database that has continuous real-time input from pharmaceutical, medical, and administrative computerized operating systems. Most psoriasis patients are treated by MHS dermatologists. Some are treated by primary
Results
The study included 46,095 patients with psoriasis and a control group of 1,579,037 MHS enrollees. The patients' characteristics appear in Table I. Age and gender distribution of patients with psoriasis is presented in Fig 1.
The Diabetes Registry includes 61,696 patients. The proportions of diabetes in patients with psoriasis and the control group are presented in Table II. The proportion of diabetes in the control group corresponds to the proportion of diabetes in Israel16 as well as to the
Discussion
In the current study we observed that psoriasis was associated with diabetes and atherosclerosis. The association was prominent in patients between 35 and 55 years of age and in women. Our study supports previous observations by Henseler and Christophers14 and other authors.3, 5, 6, 8
Previous studies have shown an increased risk of atherosclerosis in patients with systemic lupus erythematosus and rheumatoid arthritis.18, 19 Inflammation was shown to be a key factor in atherogenesis, providing a
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Funding sources: None.
Conflicts of interest: None identified.