Elsevier

Tetrahedron Letters

Volume 46, Issue 25, 20 June 2005, Pages 4315-4319
Tetrahedron Letters

A simple and efficient procedure for the synthesis of benzimidazoles using air as the oxidant

https://doi.org/10.1016/j.tetlet.2005.04.101Get rights and content

Abstract

Direct one-step synthesis of various benzimidazoles from phenylenediamines and aldehydes is described using air as the oxidant. The salient features of this method include a simple procedure, mild conditions, no coupling agents or commercial oxidants/additives used, no waste produced (only by-product being water), easy purification, and high generality.

Graphical abstract

Direct one-step synthesis of various benzimidazoles from phenylenediamines and aldehydes is described using air as the oxidant. The salient features of this method include a simple procedure, mild conditions, no coupling agents or commercial oxidants/additives used, no waste produced (only by-product being water), easy purification, and high generality.

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Acknowledgements

We would like to thank Drs. Min Ge, Changyou Zhou, and Alexander Pasternak for helpful discussions.

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