The use of quinoxaline-2-carboxylic acid and its derivatives as analytical reagents

doi:10.1016/S0003-2670(01)80403-7

Analytica Chimica Acta

Volume 41, 1968, Pages 331-339

https://doi.org/10.1016/S0003-2670(01)80403-7 Get rights and content

Abstract

Quinoxaline-2-carboxylic acid and 3-chloro and 3-hydroxy derivatives have been studied as analytical reagents. The solubility products of the metal salts, the optimum pH range for complete precipitation and the thermal behaviours of the metal complexes have been established. Quinoxaline-2-carboxylic acid allows the gravimetric determination of Cu(II), Cd(II), Zn(II), Co(II), Ni(II) and Pd(II); with the 3-chloro and 3-hydroxy derivatives, only palladium(II) could be precipitated quantitatively.

Résumé

On a examiné ĺ'acide quinoxaline-2-carboxylique et ses dérivés 3-chloro et 3-hydroxy en tant que réactifs analytiques. On a pu établir les produits de solubilité des sets métalliques, le domaine de pH optimum pour une précipitation quantitative et le comportement thermique des complexes métalliques. L'acide quinoxaline-2-carboxylique permet le dosage gravimétrique du Cu(II), Cd(II), Zn(II), Co(II), Ni(II) et Pd(II); avec les dérivés 3-chloro et 3-hydroxy, seul le palladium(II) peut être preéipité quantitativement.

Zusammenfassung

Chinoxalin-2-carboxylsäure und 3-Chloro- und 3-Hydroxy-Derivate wurden auf ihre Eignung als analytisches Reagenz untersucht. Die Löslichkeitsprodukte der Metallsalze, die optimalen pH-Bereiche zur vollständigen Fällung und das thermische Verhalten wurden aufgesucht. Chinoxalin-2-carboxylsäure gestattet die gravimetrische Bestimmung von Cu(II), Cd(II), Zn(II), Co(II), Ni(II) und Pd(II); mit den 3- Chloro- und 3-Hydroxy-Derivaten konnte nur Pd(II) quantitativ gefällt werden.

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Interaction studies of methyl acetate in aqueous solutions of quinoxaline derivatives: Effect of temperature and concentration
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Citation Excerpt :
Furthermore, they are significant with wide biological properties [4,11–16] such as antibacterial, antifungal, anticancer, antitubercular, antileishmanial, antimalarial, antidepressant, antimycobacterial, anticandida, and neurological activities, among others. There are very few reported studies in literature on the solubility of quinoxaline and its derivatives [17]. The knowledge of solubility of quinoxaline in methyl acetate at different temperatures is vital in physical stability studies of liquid dosage forms, in processes where temperature changes are involved and in the preformulation phase of new compounds where only a small quantity of the compounds is present [18].
The aim of the present work is to examine the effect of temperature and concentration on interactions of methyl acetate with aqueous solutions of quinoxaline derivatives using volumetric and acoustic properties. In addition to this, the density, ρ, and sound velocity, u, of methyl acetate in aqueous solutions of quinoxaline derivatives namely: (N-{− 3-[1-methanesulfonyl-5-(quinoxalin-6-yl)-4,5-dihydropyrazol-3-yl] phenyl} methane sulfonamide [MQDPMS]), N-{− 2-[1-acetyl-5-(quinoxalin-5-yl)-4, 5-dihydropyrazol-3-yl] phenyl} methane sulfonamide [AQDPMS], N-{− 2-[1-propanoyl-5-(quinoxalin-6-yl)-4,5-dihdro-1H-pyrazol-3-yl] phenyl} methane sulfonamide [2PQDPMS] and N-{− 3-[1-propanoyl-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-3-yl] phenyl} methane sulfonamide [3PQDPMS] have been measured at 293.15, 298.15, 303.15 and 308.15 K and at pressure p = 0.1 MPa. These data have been used to calculate the derived properties such as apparent molar volume, V_φ, and apparent molar adiabatic compressibility, k_φ, for the mixtures. The standard partial molar volume, V_φ⁰, standard partial molar volume of transfer, ΔV_φ⁰, standard partial molar adiabatic compressibility, k_φ⁰, and standard partial molar adiabatic compressibility of transfer, Δk_φ⁰, have been evaluated using Redlich–Mayer type equation. These results have been interpreted in terms of effect of temperature and concentration on interactions such as solute–solute, solute–solvent and solvent–solvent which exist in the mixtures. Furthermore, apparent molar expansivity, E_φ⁰, and Hepler's constant values, ∂²V_φ⁰/∂T², have been evaluated to support the conclusions obtained from the volumetric and acoustic studies.
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The use of quinoxaline-2-carboxylic acid and its derivatives as analytical reagents

Abstract

Résumé

Zusammenfassung

J. Inorg. & Nucl. Chem.

Z. Anal. Chem.

Mikrochem.

Z. Anal. Chem.

Z. Anal. Chem.