The Detection of Microemboli in the Middle Cerebral Artery during Cardiopulmonary Bypass: A Transcranial Doppler Ultrasound Investigation Using Membrane and Bubble Oxygenators

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Abstract

Twenty-seven patients were examined who were undergoing cardiopulmonary bypass (CPB) surgery with either a bubble oxygenator or a capillary membrane oxygenator. The latter incorporated an arterial filter and bubble trap. A noninvasive Doppler ultrasound technique is described for monitoring irregularities in the Doppler flow signals attributable to gaseous microemboli detected in the middle cerebral artery during CPB.

The ultrasound index for detecting gaseous microemboli (MEI) indicated the presence of such microemboli in 22 of the 27 patients during insertion of the aortic cannula. Measurements during CPB showed the MEI ranged from 4 to 39 in the 17 patients with a bubble oxygenator. However, all 10 patients with a membrane oxygenator had an MEI of 0.

Varying the gas flow rates in 3 patients with bubble oxygenators showed a change in MEI from 4 ± 4 (SD) at a flow rate of 2 L/min to 17 ± 9 at a flow rate of 5 L/min. This observation supports the assumption that the MEI is providing quantitative information regarding the presence of gaseous emboli in the middle cerebral artery.

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      Citation Excerpt :

      But given that up to 60% of the normal population may present with right-to-left shunt of either intracardiac or pulmonary arteriovenous malformations (Woods et al., 2010), an inexpensive means of screening such as TCD, as part of a diagnostic battery, may be very useful. Both gaseous and solid microemboli can be detected using TCD through recognition of irregularities within the Doppler signal (Padayachee et al., 1987; Deverall et al., 1988; Ringelstein et al., 1998). Although these microemboli are often clinically silent, their detection may be of prognostic value in assessing risk of stroke, and of use during cardiac or vascular surgeries where gaseous emboli may originate from the oxygenator.

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    We gratefully acknowledge the help of members of the cardiopulmonary bypass team at Guy's Hospital and the Perfusion Department at London Bridge Hospital. We are most grateful to the Coronary Artery Disease Research Association (CORDA) for financial support (T.S.P.) and to the Handicapped Children's Aid Committee for financial help with equipment.

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