Oncostatin M stimulates urokinase-type plasminogen activator activity in human synovial fibroblasts1

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Cytokine regulation of synovial cell function has been considered to be involved in the pathogenesis of rheumatoid arthritis. Synoviocyte urokinase-type plasminogen activator (u-PA) expression may be relevant to the tissue remodelling, as well as to the cell migration and transformation occurring in rheumatoid joints. We report here that purified recombinant human oncostatin M (≥ ~ 0.2 U/ml = 1 pM) stimulated within six hr the u-PA activity of non-rheumatoid synovial fibroblast-like cells and raised their u-PA mRNA levels. Oncostatin M could augment PGE2 production and DNA synthesis in these cells; however, the increase in PGE2 was small compared with that caused by IL-1. Since oncostatin M is produced by immune cells, it may have a role in immune and inflammatory reactions by interacting with fibroblast populations, such as synoviocytes, in the manner described.

References (31)

  • LinsleyP.S. et al.

    J. Biol. Chem.

    (1989)
  • DanoK. et al.

    Adv. Cancer Res.

    (1985)
  • MalikN. et al.

    Mol. Cell Biol.

    (1989)
  • ZarlingJ.M. et al.
  • BrownT.J. et al.

    J. Immunol.

    (1987)
  • HornD. et al.

    Growth Factors

    (1990)
  • HamiltonJ.A.

    J. Rheumatol.

    (1983)
  • LafyatisR. et al.

    J. Clin. Invest.

    (1989)
  • LeizerT. et al.

    Arthritis Rheum.

    (1987)
  • DayerJ.-M. et al.

    J. Clin. Invest.

    (1986)
  • ButlerD.M. et al.

    Arthritis Rheum.

    (1988)
  • GuerneP.A. et al.

    J. Clin. Invest.

    (1989)
  • ButlerD.M. et al.

    J. Rheumatol.

    (1988)
  • WerbZ. et al.

    New Engl. J. Med.

    (1977)
  • MochanE. et al.

    J. Rheumatol.

    (1984)
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    1

    This work was supported by a Program Grant from the National Health and Medical Research Council (N.H.M.R.C.) of Australia. J.A.H. in an N.H.M.R.C. Principal Research Fellow.

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