Network analysis of intermediary metabolism using linear optimization. I. Development of mathematical formalism
References (43)
- et al.
Metabolism of glutamine in lymphocytes
Metabolism
(1989) - et al.
Amino acid and protein metabolism. I. The metabolic characteristics of serially propagated cells
The central metabolic pathways of Escherichia coli: relationship between flux and control at a branch point, efficiency of conversion to biomass, and excretion of acetate
Curr. Top. Cell. Regul.
(1986)The ATP-to-oxygen stoichiometries of oxidative phosphorylation by rat liver mitochondria. An analysis of ADP-induced oxygen jumps by linear nonequilibrium thermodynamics
J. biol. Chem.
(1984)- et al.
Evidence for the oxidation of glycolytic NADH by the malate-aspartate shuttle in Ehrlich ascites tumor cells
Arch. Biochem. Biophys.
(1979) - et al.
The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. Role of mitochondrial NAD(P)+-dependent malic enzyme
J. biol. Chem.
(1984) - et al.
Malate-citrate cycle during glycolysis and glutaminolysis in Ehrlich ascites tumor cells
Biochimie
(1987) - et al.
Changes in RNA metabolism and accumulation of presumptive messenger RNA during transition from the growing to the quiescent state of cultured mouse fibroblasts
J. molec. Biol.
(1975) - et al.
Mitochondrial and cytosolic interactions in perfused rat heart. Role of coupled transamination in repletion of citric acid cycle intermediates
J. biol. Chem.
(1973) - et al.
Branch point control by the phosphorylation state of isocitrate dehydrogenase
J. biol. Chem.
(1985)
Molecular Biology of the Cell
Maximum activities of some enzymes of glycolysis, the tricarboxylic acid cycle and ketone-body and glutamine utilization pathways in lymphocytes of the rat
Biochem. J.
Control of lipid metabolism in cultured cells
Lipids
The upper and lower limits of the mechanistic stoichiometry of mitochondrial oxidative phosphorylation
Eur. J. Biochem.
On the analysis of metabolic networks
Quantitative analysis of flux along the gluconeogenic, glycolytic and pentose phosphate pathways under reducing conditions in hepatocytes isolated from fed rats
Biochem. J.
Proteins: Structures and Molecular Principles
mRNA structure and function
Prog. Nucl. Acad Res. Molec. Biol.
New perspectives on carbohydrate metabolism in tumor cells
Fat synthesis in adipose tissue: an examination of stoichiometric constraints
Biochem. J.
Practical matters in instrumentation for mammalian cell cultures
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2021, Journal of Biological ChemistryCitation Excerpt :Additionally, reductions in state 3/state u respiration were not detected at the onset of IR in humans, and observations in rodent models have demonstrated that in vitro reductions in respiratory kinetics and changes in mitochondrial ultrastructure/content follow (rather than precede) development of IR, indicating that that these changes are simply adaptive in nature (144–146). The connection between overnutrition and the development of IR is more likely mediated by substrate competition among fatty acid and glucose oxidation pathways, which is a manifestation of straightforward metabolic flux balance and allosteric feedback regulation of reaction kinetics by metabolic intermediates (147–150). In other words, these effects can be reasonably explained by the core principles of bioenergetics, rather than the presence of underlying mitochondrial pathology.
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2021, Metabolic EngineeringCitation Excerpt :This objective function presumes that biomass production is principally limited by nutrient availability. Meanwhile, a variety of alternative objective functions have also been explored (Schuetz et al., 2007; Costa et al., 2014) – e.g. optimal energy generation per substrate (Ramakrishna et al., 2001), minimized redox potential (Savinell and Palsson, 1992; Knorr et al., 2007; Sánchez et al., 2012), efficient use of enzyme capacity (Noor et al., 2016; Yeo et al., 2020) and streamlined amino acid transport (Chen et al., 2019a). Compared to microbes, mammalian cells are larger, more complex and wired for multicellularity, all of which increase the costs of homeostatic maintenance and limit proliferation.
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Present address: Department of Chemical Engineering, Cleveland State University, Cleveland, OH 44115, U.S.A.