Cell
Volume 108, Issue 2, 25 January 2002, Pages 153-164
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Cancer review
Apoptosis: A Link between Cancer Genetics and Chemotherapy

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Abstract

Defects in apoptosis underpin both tumorigenesis and drug resistance, and because of these defects chemotherapy often fails. Understanding the molecular events that contribute to drug-induced apoptosis, and how tumors evade apoptotic death, provides a paradigm to explain the relationship between cancer genetics and treatment sensitivity and should enable a more rational approach to anticancer drug design and therapy.

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Correspondence: Scott W. Lowe; e-mail: [email protected]