Cell
Volume 109, Issue 2, Supplement 1, 19 April 2002, Pages S81-S96
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Review
Missing Pieces in the NF-κB Puzzle

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Abstract

The regulation of the transcription factor NF-κB activity occurs at several levels including controlled cytoplasmic-nuclear shuttling and modulation of its transcriptional activity. A critical component in NF-κB regulation is the IκB kinase (IKK) complex. This review is focused on recent progress as well as unanswered questions regarding the regulation and function of NF-κB and IKK.

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Correspondence: Michael Karin; e-mail: [email protected]