Elsevier

The Lancet

Volume 379, Issue 9834, 23–29 June 2012, Pages 2322-2323
The Lancet

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The plight of nuns: hazards of nulliparity

https://doi.org/10.1016/S0140-6736(11)61746-7Get rights and content

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  • Pregnancy Loss and Cancer Risk: A Nationwide Observational Study

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    The latter is likely to include chronically ill and/or infertile women. We found a positive association between the group never-pregnant and later ovarian cancer and endometrial cancer, which is in accordance with previous findings [31]. The inverse association between the never-pregnant group and breast cancer was, although weak, surprising, as previous studies have demonstrated nulliparity to increase the risk.

  • Epidemiology of uterine myomas and clinical practice in Spain: An observational study

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    Nulliparity has been generally associated with an increased risk for reproductive pathologies, including breast, ovarian and uterine cancers. It has been suggested that this risk is related to the increased number of ovulatory cycles, and so might be preventable by utilization of contraceptives [18]. The statistically significant association observed between myoma volume and symptom severity confirms previous studies; that is, the clinical relevance of myoma size [19,20].

  • Reproductive Factors and Incidence of Heart Failure Hospitalization in the Women's Health Initiative

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    To our knowledge, the association between nulliparity and HFpEF has not been reported previously. The continuous ovulatory cycles uninterrupted by pregnancy that correlate with nulliparity have been reported to increase the risk of breast, ovarian, and uterine cancers (38), but are generally believed to be protective against adverse cardiac remodeling and diastolic dysfunction (39). We hypothesized that the association between nulliparity and HFpEF might be driven by the established association between infertility, a correlate of nulliparity, and CVD (17,40).

  • Non-hormonal interruption of incessant ovulation as a potential approach for ovarian cancer prevention

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    The use of hormonal contraceptives, with their potential adverse effects, is justified by their effectiveness in prevention of unwanted pregnancy. Although a suggestion has been made that oral contraceptives should be made accessible to Catholic nuns [8], they might not be appropriate or acceptable for women who have no need for contraception. In addition, many women are not eligible to use oral contraceptives, or do not select to use them.

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