Letters to the EditorALPHA-1-ANTITRYPSIN, AUTISM, AND CŒLIAC DISEASE
References (3)
Lancet
(1970)
Cited by (37)
Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms
2018, Brain, Behavior, and ImmunityCitation Excerpt :In individuals with diseases/syndromes such as irritable bowel syndrome (IBS), ulcerative colitis and Crohn’s disease, psychiatric symptoms have also been reported (Ringel and Drossman, 2001, Ringel and Drossman, 2002). Studies focused on assessing the underlying pathology of GI dysfunction in children with ASD have demonstrated low α-1-antitrypsin concentrations suggestive of intestinal protein loss (Walker-Smith and Andrews, 1972), increased intestinal permeability as measured by a lactulose:mannitol test (D'Eufemia et al., 1996, de Magistris et al., 2010) and the presence of a diffuse inflammation of the intestinal tract found after endoscopy or colonoscopy as part of clinical work up for GI symptoms (reviewed in (Buie et al., 2010)). The precise nature of this inflammation has been controversial and much debated.
Alpha-1-Antitrypsin Deficiency: Epidemiological Studies and Other AATD Associated Diseases
2017, Alpha-1-antitrypsin Deficiency: Biology, Diagnosis, Clinical Significance, and Emerging TherapiesColonic CD8 and γδ T-cel infiltration with epithelial damage in children with autism
2001, Journal of Pediatricsα<inf>1</inf>-Antitrypsin deficiency and inflammatory bowel diseases
2000, Mayo Clinic ProceedingsThe role of secretin in autistic spectrum disorders
2000, International Review of Research in Mental RetardationGastrointestinal abnormalities in children with autistic disorder
1999, Journal of Pediatrics