Functional comparison of neuronal properties in the primate posterior hippocampus and parahippocampus (area TF/TH) during different behavioural paradigms involving memory and selective attention

doi:10.1016/S0166-4328(05)80273-6

Behavioural Brain Research

Volume 53, Issues 1–2, 26 February 1993, Pages 133-149

https://doi.org/10.1016/S0166-4328(05)80273-6 Get rights and content

Monkeys were trained on a delayed match-to-sample (DMS) task. In addition a standardized behavioural trial was performed which involved an experimenter approaching the animal in certain sequence and presenting edible or other objects (‘raisin trial’). Neuronal activity of 617 units was recorded in the posterior parahippocampus (PH) and in the posterior hippocampus (H). In many cases, we compared the activity of the same neuron in different takss. 32.7% of the 455 PH neurons and 28.5% of the 130 H cells responded during the presentation of the visual stimuli in the DMS task. These responses were only midly influenced by the physical dimensions of the visual stimulus, but often depended on the context in which the stimuli were presented. There was no differential response to the second stimulus that clearly depended on the nature of the first stimulus. 6.2% of the PH units, but one in H, responded in relation to the reward. 4.4% of the PH neurons, but none in H, showed a mild response during the interstimulus interval. 38.1% of 215 PH neurons and 37.8% of 45 H cells responded during one or more phases of the raisin trial. These responses were not related to the physical dimensions of the sensory stimuli. 210 PH and 41 H units were investigated during the DMS task as well as during the raisin trial. 18.1% (PH) and 12.2% (H) of the units responded during the DMS task, but not during the raisin trial; 17.1% (PH) and 36.6% (H) responded vice versa. A response in both trials was found in 17.1% of the PH neurons, but in none of the H cells. There were also other PH unit types showing responses during different aspects of the DMS taks and even in other control paradigms, while no such overlap was encountered in H. Our results suggest a function of H and PH in the evaluation of the behavioural significance of sensory information. It may be this aspect which leads to anterograde memory disturbances after lesion of these areas. Since representation of neuronal information was found to be more specific in H, a possible function as an ‘evaluation index’ is discussed.

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^*: Present address: T.R. Vidyasagar, Division of Neuroscience, John Curtin School of Medical Research, Australian National University, GPO Box 334, Canberra, ACT 2601, Australia.

^**: Prof. Dr. Otto D. Creutzfeldt deceased in January 1992.

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Functional comparison of neuronal properties in the primate posterior hippocampus and parahippocampus (area TF/TH) during different behavioural paradigms involving memory and selective attention

J. Neurosci. Methods

Brain Res.

Behav. Brain Res.

Brain Res.

Brain Res.

Trends Neurosci.

EEG Clin. Neurophysiol.

Brain Cogn.

Neuropsychologia

Int. Rev. Neurobiol.

Physiol. Behav.

Brain Res.

EEG Clin. Neurophysiol.

Cortex

Brain Res.

Brain Res.

Brain Lang.

Nature

J. Neurosci.

Behav. Brain Res.

Prog. Brain Res.

Brain Res.

Prog. Neurobiol.

J. Physiol.

Memory: anatomical organization of candidate brain regions

Inferior parietal lobule function in spatial perception and visuomotor integration

Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia

Arch. Gen. Psychiatry

Anatomical evidence for medial pulvinar connections with the posterior cingulate cortex, the retrosplenial area, and the posterior parahippocampal gyrus in monkeys

J. Comp. Neurol.

Responses of neurons in the inferior temporal cortex in short term and serial recognition tasks

Exp. Brain Res.

On areas of transition between entorhinal allocortex and temporal isocortex in the human brain: normal morphology and lamina-specific pathology in Alzheimer's disease

Acta Neuropathol. (Berl.)

Effect of context on the response of single units recorded from the hippocampal region of behaviorally trained monkeys

Lasting consequences of bilateral medial temporal lobectomy: clinical course, and experimental findings in H.M.

Semin. Neurol.

Performance on delayed match following lesions of medial temporal lobe structures

J. Comp. Physiol. Psychol.

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Stimulus-selective properties of inferior temporal neurons in the macaque

J. Neurosci.

Functional relations among inferotemporal cortex, amygdala, and lateral hypothalamus in monkey operant feeding behavior

J. Neurophysiol.

Inferotemporal neurons distinguish and retain behaviorally relevant features of visual stimuli

Science

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J. Neurosci.

Amygdalectomy and disconnection in visual learning for auditory secondary reinforcement by monkeys

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Hippocampus

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Brain

Dynamics of the hippocampal contribution to memory: stimulation and recording studies in humans

Neural encoding of individual words and faces by the human hippocampus and amygdala

Nature