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YAC contigs and restriction maps of chromosomes 4 and 5 from the cloned line 3D7 of Plasmodium falciparum

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Acknowledgements

We wish to thank Justin Rubio and Tony Triglia for helpful discussions and advice. This work was supported by the Wellcome Trust and the National Health and Medical Research Council of Australia.

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  • The conserved genome organisation of non-falciparum malaria species: The need to know more

    2000, International Journal for Parasitology
    Citation Excerpt :

    The use of YACs allows for the stable propagation of large fragments up to 200 kb[60], whereas, in general, bacterial cloning systems appear to be limited in supporting fragment sizes over 5 kb, due to the instability of (A+T)-rich Plasmodium DNA. The information produced resulted in the assembly of physical maps of the 14 chromosomes[61, 62]and several complete or partial chromosome YAC contigs[63, 64]. In P. vivax and P. berghei, similar studies have been initiated, but on a much smaller scale.

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