Proliferation of a Subpopulation of Human Peripheral Blood Monocytes in the Presence of Colony Stimulating Factors may Contribute to the Inflammatory Process in Diseases such as Rheumatoid Arthritis

doi:10.1016/S0171-2985(00)80048-0

Immunobiology

Volume 202, Issue 1, May 2000, Pages 18-25

https://doi.org/10.1016/S0171-2985(00)80048-0 Get rights and content

Abstract

Apart from acting on hemopoietic progenitor cells, colony stimulating factors (CSFs) have been shown to be involved in the activation, survival, proliferation and differentiation of more mature cells of the monocyte/macrophage lineage. There is evidence that a proportion of human peripheral blood monocytes can proliferate in response to CSF-1, (also known as M-CSF) and granulocyte-macrophage-CSF (GM-CSF). CSFs have been shown to be at elevated levels in the synovial fluid of RA patients and thus local proliferation of monocyte/macrophage within an inflamed lesion may contribute to the local tissue hyperplasia evident in inflammatory conditions. Flow cytometric analysis of surface antigen expression and cytokine production in response to lipopolysaccharide stimulation has been used to characterise the proliferating subpopulation of monocytes. Further characterization and subsequent isolation of this subpopulation of monocytes may provide new and important information necessary in understanding inflammatory diseases such as rheumatoid arthritis, where local proliferation at the site of inflammation may be a key factor contributing to the chronicity of the disease.

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^*: Dr. Suzanne Moss, Inflammation Research Centre, The University of Melbourne, Department of Medicine, Royal Melbourne Hospital, 3010, Australia, Phone: (613) 9344 6252, Fax: (613) 9347 1863.

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Proliferation of a Subpopulation of Human Peripheral Blood Monocytes in the Presence of Colony Stimulating Factors may Contribute to the Inflammatory Process in Diseases such as Rheumatoid Arthritis

Abstract

Blood

J. Immunol. Methods

Lancet

II Depressed lymphocyte proliferation and enhanced prostanoid release from monocytes. Clin. Immunol. & Immunopathol

Lancet

Blood

The biology of the macrophage

IL-3 and granulocytemacrophage colony-stimulating factor stimulate two distinct phases of adhesion in human monocytes

J. Immunol.

Examination of survival, proliferation and cell surface antigen expression of human monocytes exposed to macrophage colony-stimulating factor (M-CSF)

Int. J. Cell Cloning

Direct comparison of the effects of CSF-1 (M-CSF) and GM-CSF on human monocyte DNA synthesis and CSF receptor expression

J. Int. Cyto. Res.

Productive HIV-1 infection of macrophages restricted to the cell fraction with proliferative capacity

EMBO

Aortic endothelial cells regulate proliferation of human monocytes in vitro via a mechanism synergistic with macrophage colony-stimulating factor

J. Clin. Invest.

Proliferation of mature and immature subpopulations of bronchoalveolar monocytes/macro phages and peripheral blood monocytes

Cell Prolif.

Alveolar macrophage replication. One mechanism for the expansion of the mononuclear phagocyte population in the chronically inflamed lung

J. Clin. Invest.

Increased macrophage division in synovial fluid of goats infected with caprine arthritis-encephalitis virus

J. Infect Dis.

Evidence for cell division in synoviocytes in acutely inflamed rabbit joints

Ann. Rheum. Dis.

The response of human peripheral blood mononuclear phagocytes to rheumatoid arthritis

J. Leukoc. Biol.