Creatinine complexes of zinc, cadmium and mercury

doi:10.1016/S0277-5387(00)88099-7

Polyhedron

Volume 3, Issue 5, 1984, Pages 619-621

https://doi.org/10.1016/S0277-5387(00)88099-7 Get rights and content

Abstract

Zinc, cadmium and mercury(II) complexes of creatinine of the composition M(Creat)₂X₂ (X = Cl, Br or I) are prepared. The complexes are characterized by analytical and spectral methods. The increase in cyclic NH stretching frequency in the case of complexes (3350 cm⁻¹) from that of the free ligand (3300 cm⁻¹) suggested that secondary nitrogen is involved in coordination. The shift in the resonances of cyclic NH proton in the ¹H NMR and carbonyl and imine carbons in ¹³C NMR when compared to the ligand indicated that cyclic nitrogen coordinates. Conductivity measurements in N, N-dimethylformamide suggested that the complexes are non-electrolytes. Thermal decomposition behaviour of the complexes is also discussed.

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Spectroscopic and structural study of the newly synthesized heteroligand complex of copper with creatinine and urea
2016, Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Citation Excerpt :
The study of the structural and chemical properties of Crn and urea is very important in life sciences, medicine and molecular physics [11–17]. In recent years various studies on different metallic complexes of Crn [18–29] and urea [30–36] have been done leading to interesting observations regarding their coordination properties. The crystal structure of Crn and its coordination complexes with certain metals have been reported using X-ray crystallography [17,18,26,27].
Study of copper complex of creatinine and urea is very important in life science and medicine. In this paper, spectroscopic and structural study of a newly synthesized heteroligand complex of copper with creatinine and urea has been discussed. Structural studies have been carried out using DFT calculations and spectroscopic analyses were carried out by FT-IR, Raman, UV–vis absorption and fluorescence techniques. The copper complex of creatinine and the heteroligand complex were found to have much increased water solubility as compared to pure creatinine. The analysis of FT-IR and Raman spectra helps to understand the coordination properties of the two ligands and to determine the probable structure of the heteroligand complex. The LIBS spectra of the heteroligand complex reveal that the complex is free from other metal impurities. UV–visible absorption spectra and the fluorescence emission spectra of the aqueous solution of Cu–Crn–urea heteroligand complex at different solute concentrations have been analyzed and the complex is found to be rigid and stable in its monomeric form at very low concentrations.
New creatinine complexes of nickel(II)
2000, Thermochimica Acta
Following recent work on creatinine complexes of copper(II), creatinine complexes of nickel(II) with various anions have been prepared for the first time and characterised by elemental analysis, solid state infrared spectroscopy and thermal analysis methods. Analysis of the gases evolved during thermal analysis with a coupled FTIR spectrometer provided support for the proposed decomposition sequence. In the case of the complex chloride, [Ni(creat)₂(H₂O)₂]Cl₂ the loss of coordinated water has been shown to be reversible.
New copper<sup>(II)</sup> complexes of Creatinine
1999, Thermochimica Acta
The importance of Creatinine in clinical chemistry is well recognized: its level in serum and urine is indicative of renal function (Creatinine Clearance Test) and it is the final metabolic product of Creatine, that participates in energy flow in the muscle tissues. It has been suggested that the metabolism of Creatinine is connected with the complexation to metal ions. However, no thermoanalytical studies on Creatinine complexes are reported in the literature. In this work, the synthesis and the thermal behavior of new Cu^(II)–Creatinine complexes are described. By the coupled TG–FT-IR technique, the proposed decomposition mechanism of the complexes is confirmed. A parallel characterization by solid state IR spectroscopy and mass spectrometry is also reported.
New transition metal binding modes for creatinine: Molecular structures of [(C<inf>4</inf>R<inf>4</inf>)Ir(C<inf>4</inf>H<inf>7</inf>N<inf>3</inf>O) (PPh<inf>3</inf>)<inf>2</inf>Cl] and [(C<inf>4</inf>R<inf>4</inf>)Ir(C<inf>4</inf>H<inf>7</inf>N <inf>3</inf>O)(PPh<inf>3</inf>)]BF<inf>4</inf>, (R = CO<inf>2</inf>CH<inf>3</inf>)
1997, Polyhedron
Reaction of [(C₄R₄)Ir(PPh₃)₂Cl] ( $4, R = CO_{2} CH_{3}$ ) and creatinine in chloroform at 23 °C gave the creatinine complex [(C₄R₄)Ir(C₄H₇N₃O)(PPh₃)₂Cl] (6) in 81% isolated yield. Reaction of the bis (acetonitrile)iridium cation [(C₄R₄)Ir(NCCH₃)₂(PPh₃)₂][BF₄] ( $5, R = CO_{2} CH_{3}$ ) and creatinine in chloroform at 23 °C gave [(C₄R₄)Ir(C₄H₇N₃O)(PPh₃)₂][BF₄] ( $7, R = CO_{2} CH_{3}$ ) in 96% isolated yield. X-ray crystallography established two unprecedented coordination modes for creatine in complexes 6 and 7. In complex 6 the creatinine is bound to iridium in a monodentate fashion through the exocyclic nitrogen, whereas creatinine serves as a bidentate η²-(N,O)-ligand in 7.
Complexes of Nickel(II) with creatinine: X-ray crystal structures and spectroscopic studies
1995, Journal of Inorganic Biochemistry
Two creatinine complexes, [Ni(en)₂(creat)₂][BPh₄]₂(1), [Ni(creat)₂(H₂O)₄]Cl₂(2) en = ethylenediamine; creat = creatinine), have been prepared by reaction of Ni(en)₂Cl₂ and [NEt₄]₂[NiCl₄], respectively, and creatinine in ethanol-water (1) and MeCN-water (2). Both complexes were obtained in the form of suitable crystals for X-ray crystallography. Complex (1) crystallizes in the triclinic space group $P 1 (#2)$ with $a = 9.940(2) A ̊$ , $b = 15.732(6) A ̊$ , $c = 9,339(3) A ̊$ , α = 96.87(3)°, β = 104.30(3)°, γ = 75.83(3)°, $V = 1369(2) A ̊^{3}$ , Z = 1, R = 0.045. Complex (2) is monoclinic, space group P2₁/c(#14) with $a = 9.196(2) A ̊$ , $b = 13.475(4) A ̊$ , β = 112.97(2)°, $V = 895.1(8)_a ̊^{3}$ , Z = 2, R = 0.039. Full-matrix least-squares refinements with anisotropic thermal displacement parameters were carried out for each structure. Different coordination modes of creatinine are observed (through the exocyclic O(1) and ring N(1), respectively) depending on the donor nature of the accompanying ligands. The crystal structure of (1) is rather unusual. The metal ion of the en complex is linked to four N atoms of two ethylenediamine ligands in the basal plane and two exocyclic O(1) atoms of two creatinine molecules in the axial positions. This is the first crystallographic evidence of monodentate exocyclic O-atom binding in creatinine. The IR and electronic spectra of the obtained compounds agree with the mode of binding derived from the structural analisis. Thermogravimetric data are in agreement with the stoichiometry and formulas proposed.
X-ray crystal structure of a ternary copper(II) peptide creatinine complex, (Aquo)(Creatinine)(Glycylglycinato) copper(II) sesquihydrate
1995, Polyhedron
The first creatinine ternary complex[Cu(gg)(H₂O)(creat)]·1.5 H₂O (1) [gg = glycylglycine (2−), creat = creatinine] has been crystallized from aqueous solution. The coordination geometry about the copper is approximately square pyramidal with the tridentate glycylglycine dianion and the N(1) of creatinine occupying the corners of a square. The coordination sphere about the copper is completed by an axial water molecule, CuOW(1) distance 2.496(2) Å. Another water molecule OW(2), CuOW(2) distance 2.907(2) Å, extends qualitatively the coordination geometry to octahedral. A third water molecule OW(3) with an occupancy factor of 0.5 is disordered and is located between two complex units. The complete crystal structure is maintained by an extensive hydrogen-bonding network in which the three types of water molecules are involved.

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NoteCreatinine complexes of zinc, cadmium and mercury

Abstract

Ann. Rev. Biochem.

Note
Creatinine complexes of zinc, cadmium and mercury