The majority of long non-stop reading frames on the antisense strand can be explained by biased codon usage
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Cited by (24)
The search for new chlorophyll-binding proteins in the cyanobacterium Synechocystis sp. PCC 6803
2012, Journal of BiotechnologyCitation Excerpt :This indicates that antisense transcript levels were sensitive to environmental conditions, which makes it plausible that they are transcribed and have functional relevance. Genes that encode enzymes have been found to contain long stretches without stop codons on their antisense strands due to a preferential codon usage on the sense strand (Boles and Zimmermann, 1994; Duax et al., 2005; John, 1997). However, as we show that the level of antisense transcripts is modified under different environmental conditions, it is very unlikely that the two ORFs are just the result of codon bias on the sense strand.
Codon usage bias and A+T content variation in human papillomavirus genomes
2003, Virus ResearchOverlapping sequences with high homology to functional proteins coexist on complementary strands of DNA in the rumen bacterium Prevotella albensis
1999, Biochemical and Biophysical Research CommunicationsStatistical properties of open reading frames in complete genome sequences
1999, Computers and Chemistry
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