Elsevier

Mechanisms of Development

Volume 98, Issues 1–2, 1 November 2000, Pages 111-114
Mechanisms of Development

Gene expression pattern
The murine A33 antigen is expressed at two distinct sites during development, the ICM of the blastocyst and the intestinal epithelium

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Abstract

The expression pattern of the murine A33 antigen has been defined during development using wholemount immunohistochemistry. Two temporally and spatially distinct sites of expression were identified: the inner cell mass of the blastocyst and the endoderm cell layer of the intestinal tract where expression is initiated at E14.5 in the hindgut and subsequently extends throughout the length of the intestine. The onset of mA33 antigen expression in the gut occurs at the beginning of an extensive phase of cell movement involved in the conversion of the endoderm cell layer to a single cell layer of polarized epithelium. Expression of mA33 antigen is then maintained into adulthood, where it is a definitive marker of intestinal epithelium.

Keywords

Mouse
Blastocyst
Inner cell mass
Intestine
A33 antigen
Ig domain
Gut
Endoderm
Epithelium
Development

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