Elsevier

Mechanisms of Development

Volume 90, Issue 2, 1 February 2000, Pages 181-193
Mechanisms of Development

CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis

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Abstract

Development of the vertebrate central nervous system is thought to be controlled by intricate cell-cell interactions and spatio-temporally regulated gene expressions. The details of these processes are still not fully understood. We have isolated a novel vertebrate gene, CRIM1/Crim1, in human and mouse. Human CRIM1 maps to chromosome 2p21 close to the Spastic Paraplegia 4 locus. Crim1 is expressed in the notochord, somites, floor plate, early motor neurons and interneuron subpopulations within the developing spinal cord. CRIM1 appears to be evolutionarily conserved and encodes a putative transmembrane protein containing an IGF-binding protein motif and multiple cysteine-rich repeats similar to those in the BMP-associating chordin and sog proteins. Our results suggest a role for CRIM1/Crim1 in CNS development possibly via growth factor binding.

Keywords

Cysteine-rich repeat
Insulin-like growth factor binding protein
Notochord
Floor plate
Motor neuron
Spinal cord
Brain
CNS development
Organogenesis
Chordin
Short gastrulation
Bone morphogenic protein
Transforming growth factor-β
Holoprosencephaly 2
Spastic Paraplegia Type 4
Hereditary essential tremor 2, Human
Mouse
C. elegans

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