8 Apoptosis, haemopoiesis and leukaemogenesis*
References (68)
- et al.
Impaired negative selection of T-cells in Hodgkin's disease antigen CD30-deficient mice
Cell
(1996) - et al.
Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia
Blood
(1994) - et al.
BCR-ABL-mediated inhibition of apoptosis with delay of G2/M transition after DNA damage: a mechanism of resistance to multiple anticancer agents
Blood
(1995) The CTL's kiss of death
Cell
(1995)- et al.
Involvement of mach, a novel mort1/fadd-interacting protease, in fas/apo-1- and TNF receptor-induced cell death
Cell
(1996) - et al.
CD40 ligand and its role in x-linked hyper-IgM syndrome
Immunology Today
(1993) - et al.
Cytotoxic T-cell-derived granzyme b activates the apoptotic protease ICE-Lap3
Current Biology
(1996) - et al.
Genetic control of programmed cell death in the nematode C. elegans
Cell
(1986) - et al.
Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death
Cell
(1993) STATs: signal transducers and activators of transcription
Cell
(1996)
Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis
Blood
Mice deficient in IL-1-beta-converting enzyme are defective in production of mature IL-1-beta and resistant to endotoxic shock
Cell
Mice lacking both macrophage- and granulocyte-macrophage colony-stimulating factor have macrophages and coexistent osteopetrosis and severe lung disease
Blood
Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3
Cell
Flice, a novel FADD-homologous ICE/ced-3-like protease, is recruited to the CD95 (Fas/Apo-1) death-inducing signaling complex
Cell
Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the Interleukin-1 beta converting enzyme
Cell
Apoptosis in bone marrow biopsy samples involving stromal and hematopoietic cells in 50 patients with myelodysplastic syndromes
Blood
The effect of bcr-abl antisense oligonucleotide on DNA synthesis and apoptosis in K562 chronic myeloid leukemia cells
Leukemia Research
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
Cell
Bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
Cell
Leukemia and lymphoma in ataxia telangectasia
Blood
Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair
Cell
Crystal structure of the cysteine protease interleukin-1-β-converting enzyme: A (p20/p10)2 homodimer
Cell
Influence of growth factors and substrates on differentiation of haemopoietic stem cells
Current Opinion in Cell Biology
The C. elegans cell death gene ced 3 encodes a protein similar to mammalian interleukin 1 beta converting enzyme
Cell
Erythropoietin-dependent inhibition of apoptosis is supported by carboxyl-truncated receptor forms and blocked by dominant-negative forms of Jak2
Journal of Biological Chemistry
Mammalian cell death proteases—a family of highly conserved aspartate specific cysteine proteases
Journal of Cellular Biochemistry
Bcl 2 blocks p53 dependent apoptosis
Molecular and Cellular Biology
Thymocyte apoptosis induced by p53-dependent and independent pathways
Nature
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Nature
The repression of apoptosis by activated abl oncogenes in chronic myelogenous leukaemia
Leukemia
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
Journal of Cellular Biology
Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death
Janus kinases in cytokine signalling
Philosophical Transactions of the Royal Society of London Series B: Biological Sciences
Cited by (14)
Effect of Cx43 gene-modified leukemic bone marrow stromal cells on the regulation of Jurkat cell line in vitro
2012, Leukemia ResearchCitation Excerpt :In addition, the bone marrow microenvironment provides a primary site in which residual leukemic cells may survive standard chemotherapy [35]. Because inducing apoptosis is the main mechanism for many chemotherapeutic drugs to inhibit the growth of leukemic cells [36–38], using chemotherapy drugs that can induce apoptosis in leukemic cells may enhance the anti-tumor effect on highly proliferative Jurkat cells. In light of this, we examined the cytotoxicity of MTX on Jurkat cells co-cultured with leukemic BMSCs.
Association of reticular cells with CD34+/Sca-1+ apoptotic cells in the hemopoietic organ of grasshopper, Euprepocnemis shirakii
2004, Journal of Insect PhysiologyMammalian mitochondrial IAP binding proteins
2003, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Over-expression of other active serine proteases, for example proteinase K, also results in apoptosis [59], but in this case cell death is clearly not the physiological role of the protease. The analysis of the role of putative apoptotic proteins is complicated because apoptosis is a common response to cell stress [60]. Over-expression or deletion of genes, addition of drugs or physical changes to a cell’s environment often provokes an apoptotic stress response.
Apoptosis: Ser o no ser, ésa es la cuestión
2000, Medicina ClinicaSelf-renewal, differentiation or death: Regulation and manipulation of hematopoietic stem cell fate
1999, Molecular Medicine TodayFlt3 ligand can promote survival and macrophage development without proliferation in myeloid progenitor cells
1999, Experimental Hematology
- *
Dr Ekert is supported by an NH and MRC post-graduate medical research fellowship. Dr Vaux is supported by the Anti-Cancer Council of Victoria and the Cancer Research Institute of New York.